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Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans
- S. Muthukumaraswamy, R. Edden, Derek K. Jones, J. Swettenham, K. Singh
- Biology, PsychologyProceedings of the National Academy of Sciences
- 19 May 2009
The results are supportive of recent theories suggesting that these functional neuroimaging metrics are dependent on the excitation/inhibition balance in an individual's cortex and have important implications for the interpretation of functional imaging results, particularly when making between-group comparisons in clinical research.
Neural correlates of the LSD experience revealed by multimodal neuroimaging
- R. Carhart-Harris, S. Muthukumaraswamy, D. Nutt
- Psychology, BiologyProceedings of the National Academy of Sciences
- 11 April 2016
Three complementary neuroimaging techniques, implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects, contributing important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics.
The Processing of First- and Second-Order Motion in Human Visual Cortex Assessed by Functional Magnetic Resonance Imaging (fMRI)
- Andrew T. Smith, M. Greenlee, K. Singh, F. M. Kraemer, J. Hennig
- PsychologyThe Journal of Neuroscience
- 15 May 1998
The results are consistent with the hypothesis that first-order motion sensitivity arises in V1, that second- order motion is first represented explicitly in V3 and VP, and that V5 (and perhaps also V3A and V3B) is involved in further processing of motion information, including the integration of motion signals of the two types.
The cortical topography of human swallowing musculature in health and disease
It is demonstrated that swallowing musculature is discretely and somatotopically represented on the motor and premotor cortex of both hemispheres but displays interhemispheric asymmetry, independent of handedness.
A new approach to neuroimaging with magnetoencephalography
It is suggested that the success of the beamformer technique, despite the assumption that there are no linear interactions between the mesoscopic local field potentials across distinct cortical areas, may tell us something of the balance between functional integration and segregation in the human brain.
Broadband Cortical Desynchronization Underlies the Human Psychedelic State
- S. Muthukumaraswamy, R. Carhart-Harris, D. Nutt
- Biology, PsychologyThe Journal of Neuroscience
- 18 September 2013
The findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells.
Long-term reorganization of human motor cortex driven by short-term sensory stimulation
Increased sensory input can drive long-term cross-system changes in motor areas of the cerebral cortex, which suggests that sensory stimulation might rehabilitate dysphagia, a frequent consequence of cerebral injury.
Orientation Discrimination Performance Is Predicted by GABA Concentration and Gamma Oscillation Frequency in Human Primary Visual Cortex
- R. Edden, S. Muthukumaraswamy, T. Freeman, K. Singh
- Psychology, BiologyThe Journal of Neuroscience
- 16 December 2009
It is shown that individual performance on a visual orientation discrimination task is correlated with both the resting concentration of GABA and the frequency of stimulus-induced gamma oscillations in human visual cortex, and a key role is suggested for GABAergic gamma oscillation frequency in visual discrimination tasks.
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
Brain activity was studied by fMRI in 18 healthy subjects during stimulation of the thenar eminence of the hand with either warm (non-painful, 40 degrees C) or hot (painful) stimuli using a contact thermode to discuss the role of the insula in thermosensation and attention.