• Publications
  • Influence
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
Of Microbes and Cancer Inflammation is a well-established driver of tumorigenesis. For example, patients with inflammatory bowel disease have an elevated risk of developing colorectal cancer (CRC).Expand
  • 1,174
  • 54
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
Intestinal bacteria are implicated increasingly as a pivotal factor in the development of Crohn's disease, but the specific components of the complex polymicrobial enteric environment driving theExpand
  • 530
  • 24
The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease.
Feline inflammatory bowel disease (IBD) is the term applied to a group of poorly understood enteropathies that are considered a consequence of uncontrolled intestinal inflammation in response to aExpand
  • 145
  • 15
  • PDF
Naturally acquired leptospirosis in 36 dogs: serological and clinicopathological features.
Case records of 36 dogs with confirmed leptospirosis diagnosed at the New York State College of Veterinary Medicine from 1980 to 1995 were reviewed retrospectively, and clinical, serological andExpand
  • 140
  • 13
Helicobacter infection in dogs and cats: facts and fiction.
The discovery of the spiral bacterium Helicobacter pylori and its causative role in gastric disease in humans has brought a dramatic change to gastroenterology. Although spiral bacteria have beenExpand
  • 115
  • 10
  • PDF
Specific Strains of Escherichia coli Are Pathogenic for the Endometrium of Cattle and Cause Pelvic Inflammatory Disease in Cattle and Mice
Background Escherichia coli are widespread in the environment and pathogenic strains cause diseases of mucosal surfaces including the female genital tract. Pelvic inflammatory disease (PID; metritis)Expand
  • 206
  • 9
  • PDF
Cloning and Molecular Characterization of an Immunogenic LigA Protein of Leptospira interrogans
ABSTRACT A clone expressing a novel immunoreactive leptospiral immunoglobulin-like protein A of 130 kDa (LigA) from Leptospira interrogans serovar pomona type kennewicki was isolated by screening aExpand
  • 151
  • 9
  • PDF
Complex disease and phenotype mapping in the domestic dog
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertakeExpand
  • 118
  • 9
Adherent and Invasive Escherichia coli Is Associated with Granulomatous Colitis in Boxer Dogs
ABSTRACT The mucosa-associated microflora is increasingly considered to play a pivotal role in the pathogenesis of inflammatory bowel disease. This study explored the possibility that an abnormalExpand
  • 222
  • 8
  • PDF
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival
Significance This study provides insights into the physiological role of Sel1L, an adaptor protein for the ubiquitin ligase Hrd1 in endoplasmic reticulum-associated degradation (ERAD). Using bothExpand
  • 85
  • 8
  • PDF