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Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
BackgroundThe apicomplexan parasite Plasmodium falciparum causes the most severe form of malaria in humans. After invasion into erythrocytes, asexual parasite stages drastically alter their host cellExpand
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Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes
The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions, called invasion pathways, to invade the host erythrocyte. Strains of P. falciparum vary in theirExpand
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FIRMA: a method for detection of alternative splicing from exon array data
TLDR
We present a method, finding isoforms using robust multichip analysis (FIRMA), for detecting differential alternative splicing in exon array data. Expand
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affylmGUI: a graphical user interface for linear modeling of single channel microarray data
SUMMARY affylmGUI is a graphical user interface (GUI) to an integrated workflow for Affymetrix microarray data. The user is able to proceed from raw data (CEL files) to QC and pre-processing, andExpand
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Quality Assessment of Affymetrix GeneChip Data
This chapter covers quality assessment for Affymetrix GeneChip data. The focus is on procedures available from the affy and affy-PLM packages. Initially some exploratory plots provided by the affyExpand
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aroma.affymetrix: A generic framework in R for analyzing small to very large Affymetrix data sets in bounded memory
Summary: We have developed a cross-platform open-source framework for analyzing Affymetrix data sets consisting of 1 to 1,000s of arrays. By working directly with CDF and CEL files (standardExpand
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Integrative analysis of RUNX1 downstream pathways and target genes
BackgroundThe RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for aExpand
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Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria.
The primary pathophysiological events contributing to fatal malaria are the cerebral syndrome, anemia, and lactic acidosis. The molecular basis of each event has been unclear. In the present study,Expand
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Invasion by P. falciparum Merozoites Suggests a Hierarchy of Molecular Interactions
Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria,Expand
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Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome
Background Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. Methodology/Principal Findings To understand how trisomy 21Expand
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