K. Simin

Publications49
h-index17
Citations2,528
Highly Influential Citations139
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Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
TLDR
Although no single mouse model recapitulated all the expression features of a given human subtype, these shared expression features provide a common framework for an improved integration of murine mammary tumor models with human breast tumors. Expand
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
TLDR
It is found that transcriptional activation mediated by the Gli family of transcription factors, although dispensable for pancreatic development, is required for Kras-induced proliferation and survival in primary pancreatic epithelial cells in culture and forKras-driven pancreatic intraepithelial neoplasia and PDAC formation in vivo. Expand
A functional Notch–survivin gene signature in basal breast cancer
TLDR
A Notch-1–survivin functional gene signature is a hallmark of basal breast cancer, and may contribute to disease pathogenesis, and Antagonists of Notch and survivin currently in the clinic may be tested as novel molecular therapy for these recurrence-prone patients. Expand
GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation
Repository Citation Goel HL, Pursell BM, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. (2013). GLI1 regulates a… Expand
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
TLDR
Findings reveal a novel autocrine pathway involving VEGF/NRP2, α6β1 and GLI1 that contributes to the initiation of T NBC and support the feasibility of NRP2‐based therapy for the treatment of TNBC that targets and impedes the function of TICs. Expand
Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family
TLDR
The Drosophila punt gene encodes atr-II, a previously described type II receptor that on its own is able to bind activin but not BMP2, a vertebrate ortholog of dpp, which is suggested to function as a type II receptors for dpp. Expand
Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells.
TLDR
It is shown that aldehyde dehydrogenase (ALDH) activity is indicative of radioresistant prostate progenitor cells with an enhanced DNA repair capacity and activation of epithelial-mesenchymal transition (EMT). Expand
Analysis of Integrin β4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance
TLDR
Observations indicate that β4 expression in human breast cancer is restricted and associated with basal-like cancers, and they support the hypothesis thatβ4 may function in concert with a discrete set of proteins to facilitate the aggressive behavior of a subset of tumors. Expand
pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia
TLDR
It is reported that mouse mammary epithelium is similar in its requirements for pRbf function; Rbf inactivation by T121, a fragment of SV40 T antigen that binds to and inactivates pRBF proteins, increases proliferation and apoptosis. Expand
Genetic analysis of punt, a type II Dpp receptor that functions throughout the Drosophila melanogaster life cycle.
TLDR
It is suggested that the Punt protein functions as a dimer or higher order multimer throughout the Drosophila life cycle, and the tight correspondence between both embryonic and postembryonic loss-of-function punt and dpp phenotypes implicates a role for Punt in mediating virtually all Dpp signaling events. Expand
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