Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
- J. Herschkowitz, K. Simin, C. Perou
- Biology, MedicineGenome Biology
- 10 May 2007
Although no single mouse model recapitulated all the expression features of a given human subtype, these shared expression features provide a common framework for an improved integration of murine mammary tumor models with human breast tumors.
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
- M. Rajurkar, W. E. De Jesus-Monge, J. Mao
- BiologyProceedings of the National Academy of Sciences
- 9 April 2012
It is found that transcriptional activation mediated by the Gli family of transcription factors, although dispensable for pancreatic development, is required for Kras-induced proliferation and survival in primary pancreatic epithelial cells in culture and forKras-driven pancreatic intraepithelial neoplasia and PDAC formation in vivo.
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
- H. Goel, B. Pursell, A. Mercurio
- BiologyEMBO Molecular Medicine
- 21 February 2013
Findings reveal a novel autocrine pathway involving VEGF/NRP2, α6β1 and GLI1 that contributes to the initiation of T NBC and support the feasibility of NRP2‐based therapy for the treatment of TNBC that targets and impedes the function of TICs.
A functional Notch–survivin gene signature in basal breast cancer
- C. Lee, K. Simin, D. Altieri
- Biology, MedicineBreast Cancer Research
- 24 November 2008
A Notch-1–survivin functional gene signature is a hallmark of basal breast cancer, and may contribute to disease pathogenesis, and Antagonists of Notch and survivin currently in the clinic may be tested as novel molecular therapy for these recurrence-prone patients.
Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells.
- Monica Cojoc, C. Peitzsch, A. Dubrovska
- Biology, MedicineCancer Research
- 1 April 2015
It is shown that aldehyde dehydrogenase (ALDH) activity is indicative of radioresistant prostate progenitor cells with an enhanced DNA repair capacity and activation of epithelial-mesenchymal transition (EMT).
Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family
- A. Letsou, K. Arora, M. O’Connor
- BiologyCell
- 24 March 1995
GLI1 regulates a novel neuropilin-2/alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation
- H. Goel, B. Pursell, A. Mercurio
- Biology
- 2014
It is shown that GLI1 regulates a novel neuropilin-2/ alpha6beta1 integrin based autocrine pathway that contributes to breast cancer initiation and is cytogenetically significant in women diagnosed with breast cancer.
Analysis of Integrin β4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance
- Shaolei Lu, K. Simin, Ashraf Khan, A. Mercurio
- Biology, MedicineClinical Cancer Research
- 15 February 2008
Observations indicate that β4 expression in human breast cancer is restricted and associated with basal-like cancers, and they support the hypothesis thatβ4 may function in concert with a discrete set of proteins to facilitate the aggressive behavior of a subset of tumors.
pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia
- K. Simin, Hua‐Lang Wu, T. Dyke
- BiologyPLoS Biology
- 1 February 2004
It is reported that mouse mammary epithelium is similar in its requirements for pRbf function; Rbf inactivation by T121, a fragment of SV40 T antigen that binds to and inactivates pRBF proteins, increases proliferation and apoptosis.
The Drosophila Gene for Antizyme Requires Ribosomal Frameshifting for Expression and Contains an Intronic Gene for snRNP Sm D3 on the Opposite Strand
- Igor P. Ivanov, K. Simin, A. Letsou, J. F. Atkins, R. Gesteland
- BiologyMolecular and Cellular Biology
- 1 March 1998
The present work shows that defects in either snRNP Sm D3 or antizyme, or both, are likely causes of the gutfeelingphenotype of embryonic lethality and aberrant neuronal and muscle cell differentiation.
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