K. Simansky

Publications35
h-index20
Citations1,348
Highly Influential Citations47
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New evidence for neurotransmitter influences on brain development
The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new… Expand
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Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats
The endocannabinoid system is emerging as an integral component in central and peripheral regulation of feeding and energy balance. Our investigation analyzed behavioral roles for cannabinoid… Expand
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Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats
Abstract Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food… Expand
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Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake.
Neurons that synthesize the morphine modulatory peptide neuropeptide FF (NPFF; Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) densely innervate the parabrachial nucleus (PBN), an area implicated in regulating… Expand
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Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats
gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus… Expand
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The Serotonergic 5-HT2C Agonist m-Chlorophenylpiperazine Increases Weight-Supported Locomotion without Development of Tolerance in Rats with Spinal Transections
The direct serotonergic agonist, m-chlorophenylpiperazine (m-CPP), displays high efficacy at 5-HT(2C) receptors. Systemic administration of m-CPP increased dramatically the percentage of… Expand
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Parabrachial infusion of d-fenfluramine reduces food intake: Blockade by the 5-HT1B antagonist SB-216641
Systemic administration of the serotonin (5-HT) releaser/reuptake inhibitor, D-fenfluramine decreases consumption of food in mammals. This hypophagic action involves loci at several levels of the… Expand
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CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety
Abstract The selective 5-HT1B agonist CP-94,253 (3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b] pyridine) (5–40 μmol/kg) reduced the intake of both pellets and a 10% solution of sucrose… Expand
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Mu‐opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating
Acute pharmacological studies have implicated mu‐opioid receptors (MORs) in the shell of the nucleus accumbens (NAC) in mediating responses for palatable food and other natural and drug‐induced… Expand
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The CCK-A receptor antagonist, devazepide, blocks the anorectic action of CCK but not peripheral serotonin in rats
A role has been proposed for cholecystokinin (CCK)-A-type receptors in mediating the anorectic action produced by serotonergic stimulation in rats. We examined the effect of pretreatment with the… Expand
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