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Genetic diversity and evidence for population admixture in Batak Negritos from Palawan.
- Clarissa Scholes, K. Siddle, +11 authors A. Migliano
- Geography, Medicine
- American journal of physical anthropology
- 1 September 2011
Anthropologists have long been fascinated by the isolated hunter-gatherer populations in Southeast Asia (SEA) collectively known as "Negritos." However, the origins and affinities of these groups… Expand
Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs
The optimal coordination of the transcriptional response of host cells to infection is essential for establishing appropriate immunological outcomes. In this context, the role of microRNAs (miRNAs) –… Expand
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.
- K. Siddle, M. Deschamps, +10 authors L. Quintana-Murci
- Biology, Medicine
- Genome research
- 30 January 2014
MicroRNAs (miRNAs) are critical regulators of gene expression, and their role in a wide variety of biological processes, including host antimicrobial defense, is increasingly well described.… Expand
The Red Queen's long race: human adaptation to pathogen pressure.
- K. Siddle, L. Quintana-Murci
- Biology, Medicine
- Current opinion in genetics & development
- 1 December 2014
Pathogens, and the infectious diseases they cause, have been paramount among the threats encountered by humans in their expansions throughout the globe. Numerous studies have identified immunity and… Expand
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely… Expand
Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood.
In blood samples from patients with viral infection, it is often important to separate viral particles from human cells, for example, to minimize background in performing viral whole genome… Expand
Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.
SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and… Expand
Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery.
- Kayla G. Barnes, Jason Kindrachuk, +11 authors Daniel S. Chertow
- Clinical infectious diseases : an official…
- 15 October 2017
In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no… Expand
Co-circulating mumps lineages at multiple geographic scales
Despite widespread vaccination, eleven thousand mumps cases were reported in the United States (US) in 2016–17, including hundreds in Massachusetts, primarily in college settings. We generated 203… Expand
Capturing sequence diversity in metagenomes with comprehensive and scalable probe design
- Hayden C. Metsky, K. Siddle, +44 authors Christian B. Matranga
- Computer Science, Medicine
- Nature Biotechnology
- 1 February 2019
A sensitive method to analyze metagenomes, CATCH, enables detection and characterization of diverse viral sequences, including the 356 viruses known to infect humans. Expand