K. Shinozuka

Publications227
h-index35
Citations3,685
Highly Influential Citations102
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Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation.
An attempt was made to elucidate the molecular targetfor the antitumor effects of cordycepin (3'-deoxyadenosine) using non-selective and selective adenosine A1, A2a, A2b and A3 receptor agonists and… Expand
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Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats.
We examined the effect of Ginkgo biloba extract (GBE) on hepatic drug-metabolizing enzymes, particularly cytochrome P450 (CYP), in rats. Rats were fed a GBE-containing diet or received GBE by… Expand
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Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany and is ingested widely as a herbal medicine in some countries. However, accurate… Expand
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Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.
The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein,… Expand
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Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs
In a search for substances related to the marked induction of hepatic cytochrome P450 (CYP) by ginkgo biloba extract (GBE), mice were given either GBE (1000 mg kg−1) or fractions of GBE for 5 days.… Expand
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Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats.
Conventional noninvasive blood pressure in conscious rats or mice are typically measured using the tail-cuff method after heating the animal. The goal of this study was to assess the validity of a… Expand
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Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany. In the present study, to clarify the pharmacological properties of vasodilation… Expand
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Role of adenosine in insulin-stimulated release of leptin from isolated white adipocytes of Wistar rats.
Leptin, the ob gene product that can decrease caloric intake and increase energy expenditure, is functionally released by insulin from adipose tissue. Adenosine is thought to be an important… Expand
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Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats
In a previous study, we found that orally administered Ginkgo biloba extract (GBE) induced hepatic cytochrome P450 (CYP) in rats, especially the CYP2B type. This fact suggested that GBE influenced… Expand
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Characterization of mouse melanoma cell lines by their mortal malignancy using an experimental metastatic model.
We characterized the metastatic ability and mortality of four different mouse melanoma cell lines, B16-F0, -F1, -F10 and -BL6. B16-F0 is the parent cell line. B16-F1 was obtained by a one-time… Expand
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