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  • Influence
Alpinia officinarum Stimulates Osteoblast Mineralization and Inhibits Osteoclast Differentiation.
It is demonstrated that WEAO stimulates osteoblast mineralization and inhibits osteoclast differentiation, indicating it may be a promising herbal candidate to treat or prevent pathological bone diseases by regulating the balance between osteOClast and osteOBlast activity. Expand
Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption
It is demonstrated that water extract of the stem of Spatholobus suberectus (WESS) inhibits osteoclast differentiation and function, and suggests that WESS has a potential for treating pathological bone diseases caused by excessive bone resorption. Expand
Inhibitory effect of cantharidin on osteoclast differentiation and bone resorption
The results suggested that cantharidin-mediated inactivation of PP2A could prevent RANKLinduced activation of ERK/MAP kinase and transcription factors such as AP-1 and NFATc1, with subsequent inhibition of osteoclast-specific gene expression required for efficient osteOClast differentiation and bone resorption. Expand
The anti-osteoporotic effect of Yijung-tang in an ovariectomized rat model mediated by inhibition of osteoclast differentiation.
It is suggested that YJ possess potent anti-osteoporotic activity in OVX rats and may be a useful remedy for the treatment of postmenopausal osteoporosis. Expand
Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
Data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism, and this study evaluated the stimulatory effects of machilin A and structurally related lignan isolated from Hispana fragrans on osteoblast differentiation. Expand
Artemisia capillaris Alleviates Bone Loss by Stimulating Osteoblast Mineralization and Suppressing Osteoclast Differentiation and Bone Resorption.
It is demonstrated that WEAC has a beneficial effect on bone loss through the regulation of osteoblast mineralization, as well as osteoclast formation and bone resorption. Expand
Pine needles attenuate receptor activator for nuclear factor-B ligand (RANKL)-induced trabecular bone loss by inhibiting osteoclast differentiation
  • K. Shim, J. Ma
  • Chemistry, Medicine
  • Integrative medicine research
  • 3 July 2018
WEPN inhibition on osteoclastogenesis could contribute to attenuate RANKL-induced trabecular bone loss in vivo and suggest that WEPN could be prescribed in traditional medicine or used in health functional food to prevent or treat osteoporotic bone diseases. Expand
Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function
It is found that water extract of the stem of Acer tegmentosum (WEAT) inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteocline differentiation. Expand
Corosolic acid stimulates osteoblast differentiation by activating transcription factors and MAP kinases
Results suggest that the anabolic effects of corosolic acid upon osteoblast differentiation could result from its activation of transcription factors and MAP kinases. Expand
Yukmijihwang-tang inhibits receptor activator for nuclear Factor-κB ligand-induced osteoclast differentiation.
Quantitative reverse transcription-polymerase chain reaction showed that YMT significantly decreased RANKL-induced expression of osteoclast differentiation-specific genes (TRAP, matrix metalloproteinase-9, cathepsin K, and the d2 isoform of vacuolar ATPase V(0) domain), suggesting that Y MT may have therapeutic potential in bone diseases. Expand