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Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress.
Endothelial cells secrete prothrombotic ultralarge von Willebrand factor (VWF) multimers, and the metalloprotease ADAMTS13 cleaves them into smaller, less dangerous multimers. This reaction isExpand
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Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice.
  • J. Xue, Q. Wu, +6 authors J. Sadler
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 23 June 1998
Deficiency of blood coagulation factor V or tissue factor causes the death of mouse embryos by 10.5 days of gestation, suggesting that part of the blood coagulation system is necessary forExpand
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  • Open Access
A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury.
Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and heterozygous state, suggesting thatExpand
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  • Open Access
Control of Drosophila retinoid and fatty acid binding glycoprotein expression by retinoids and retinoic acid: northern, western and immunocytochemical analyses.
In Drosophila, thorough retinoid deprivation is possible, optimizing investigation of the effects of vitamin A metabolites and retinoic acid on the visual system. Retinoids had been found to controlExpand
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Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary renal disease with no currently available targeted therapies. Based on the established connection between β-cateninExpand
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ULTRASTRUCTURAL STUDIES ON THE ALLOTRANSPLANTED PANCREAS IN DOGS
SUMMARY In dogs, the rejection of the allotransplanted pancreas was studied using the electron microscope. Eighteen pancreatic grafts were examined 48 hr to 10 days after transplantation withoutExpand
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Serial Histologic Study of the Development, Progression, and Healing of Acute Pancreatitis in the Rat
This study was undertaken to investigate serially the development, progression, and healing of acute pancreatitis which was induced in rats by the closed duodenal loop technique. Edematous changesExpand
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Electron microscopic studies of human pancreatic adenocarcinoma.
Tissue samples from 12 patients with pancreatic carcinoma were studied by light and electron microscopy. Ten were diagnosed as adenocarcinoma by light microscopy. However, three different electronExpand
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Centrosome amplification disrupts renal development and causes cystogenesis
Centrosome number is tightly controlled to ensure proper ciliogenesis, mitotic spindle assembly, and cellular homeostasis. Centrosome amplification (the formation of excess centrosomes) has beenExpand
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