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Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice
A close relationship between synaptic plasticity and synapse formation in the cerebellum is suggested by analyses of the GluR delta 2 mutant mice, which reveal that the delta 2 subunit plays important roles in motor coordination, formation of parallel fiber-Purkinje cell synapses and climbing fiber- Purkinjecell synapses, and long-term depression of parallel Fiber-Purkinshire cell synaptic transmission. Expand
Dynamic Imaging of Somatosensory Cortical activity in the Rat Visualized by Flavoprotein Autofluorescence
Activity‐dependent changes in the autofluorescence of flavoproteins are useful for functional brain imaging in vivo and were resistant to an inhibitor of nitric oxide synthase, while the latter was inhibited. Expand
Deficient Cerebellar Long-Term Depression, Impaired Eyeblink Conditioning, and Normal Motor Coordination in GFAP Mutant Mice
The data support the notion that cerebellar LTD is a cellular mechanism closely associated with eyeblink conditioning, but is not essential for motor coordination tasks tested, and suggest that GFAP is required for communications between Bergmann glia and Purkinje cells during LTD induction and maintenance. Expand
Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum
It is demonstrated that the release of endogenous NO is essential for the induction of synaptic plasticity in the cerebellum and that exogenous NO or cGMP can substitute for the stimulation of climbing fibres to cause long-term depression in rat cerebellar slices. Expand
The Extrageniculate Visual Pathway Generates Distinct Response Properties in the Higher Visual Areas of Mice
The preservation of visual property differences among the higher visual areas following V1 lesions and their loss following SC lesions indicate that pathways from the SC through the thalamus to higher cortical areas are sufficient to support these differences. Expand
cAMP-Dependent Long-Term Potentiation of Nitric Oxide Release from Cerebellar Parallel Fibers in Rats
Data indicate that neural NO release is under activity-dependent control, just as synaptic transmitter release is, and might play a role in cross talk between presynaptic and postsynaptic plasticity by facilitating NO–cGMP-dependent post Synaptic LTD after induction of cAMP-dependent presynptic LTP and LTPNO. Expand
An electrochemical microprobe for detecting nitric oxide release in brain tissue
  • K. Shibuki
  • Medicine, Biology
  • Neuroscience Research
  • 1 September 1990
The results ensure that the NO probes developed in this study effectively detect the endogenous NO release in brain tissue. Expand
Enduring Critical Period Plasticity Visualized by Transcranial Flavoprotein Imaging in Mouse Primary Visual Cortex
Significant ocular dominance plasticity was observed in responses elicited by moving grating patterns, but no long-lasting effect was found in visual responses eliciting by light-emitting diode light stimuli. Expand
Dynamic properties of nitric oxide release from parallel fibres in rat cerebellar slices.
The data indicate that NO is derived mainly from parallel fibres, and the relationship between NO release and cerebellar synaptic plasticity is discussed. Expand
Cerebellar long‐term potentiation under suppressed postsynaptic Ca2+ activity
It is suggested that postsynaptic Ca2+ activity in Purkinje cells is negatively correlated to the direction of plastic changes and that the Ca2+. Expand