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Stimulus onset quenches neural variability: a widespread cortical phenomenon
Neural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials. Many studies have examined the effect of a stimulus on the meanExpand
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Context-dependent computation by recurrent dynamics in prefrontal cortex
Prefrontal cortex is thought to have a fundamental role in flexible, context-dependent behaviour, but the exact nature of the computations underlying this role remains largely unknown. In particular,Expand
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A High-Performance Neural Prosthesis Enabled by Control Algorithm Design
We present a new control algorithm, the recalibrated feedback intention–trained Kalman filter (ReFIT-KF) that incorporates assumptions about the nature of closed-loop neural prosthetic control. Expand
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Gaussian-process factor analysis for low-dimensional single-trial analysis of neural population activity
We first describe extensions of the two-stage methods that allow the degree of smoothing to be chosen in principled way and that account for spiking variability, which may vary both across neurons and across time. Expand
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Neural Variability in Premotor Cortex Provides a Signature of Motor Preparation
We present experiments and analyses designed to test the idea that firing rates in premotor cortex become optimized during motor preparation, approaching their ideal values over time. We measured theExpand
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Mechanisms of Heading Perception in Primate Visual Cortex
When we move forward while walking or driving, what we see appears to expand. The center or focus of this expansion tells us our direction of self-motion, or heading, as long as our eyes are still.Expand
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A neural network that finds a naturalistic solution for the production of muscle activity
It remains an open question how neural responses in motor cortex relate to movement. We explored the hypothesis that motor cortex reflects dynamics appropriate for generating temporally patternedExpand
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A high-performance brain–computer interface
We present the design and demonstration, using electrode arrays implanted in monkey dorsal premotor cortex, of a manyfold higher performance BCI than previously reported. Expand
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An optogenetic toolbox designed for primates
Optogenetics is a technique for controlling subpopulations of neurons in the intact brain using light. This technique has the potential to enhance basic systems neuroscience research and to informExpand
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Cortical control of arm movements: a dynamical systems perspective.
Our ability to move is central to everyday life. Investigating the neural control of movement in general, and the cortical control of volitional arm movements in particular, has been a major researchExpand
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