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Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
TLDR
The molecular mechanisms controlling hepatic gluconeogenesis and glycogen storage are reviewed, and the prospect of therapeutically targeting associated pathways to treat type 2 diabetes is assessed. Expand
Molecular pathophysiology of hepatic glucose production.
TLDR
The molecular mechanisms controlling HGP in response to nutritional and hormonal signals are reviewed and discussed and how these signals are altered in T2DM are discussed. Expand
Insulin regulation of gluconeogenesis
TLDR
In individuals with compromised insulin signaling, such as insulin resistance in type 2 diabetes, insulin fails to suppress hepatic gluconeogenesis, even in the fed state; hence, an insight into these insulin‐moderated pathways is critical for therapeutic purposes. Expand
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
TLDR
A high-throughput chemical screen platform is designed and small molecules that increase PGC-1α acetylation, suppress gluconeogenic gene expression, and reduce glucose production in hepatocytes are identified that improve glucose homeostasis in dietary and genetic mouse models of T2D. Expand
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis
ETOC: Caenorhabditis elegans lacking both Ce-emerin and LEM-2 show that these proteins are essential for development of specific lineages, mitosis in somatic cells, and smooth muscle activity.Expand
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans
TLDR
C. elegans is used to study the response to nonanesthetic CO2 levels and results suggest specific physiological and molecular responses to hypercapnia, which appear to be independent of early heat shock and HIF mediated pathways. Expand
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
TLDR
It is found that CDC-like kinase 2 (CLK2) is expressed in BAT and upregulated upon refeeding and suggested that CLK2 is a regulatory component of diet-induced thermogenesis in BAT through increased CREB-dependent expression of UCP1. Expand
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator*
TLDR
It is shown that methionine and derived-sulfur metabolites in the transamination pathway activate the GCN5 acetyltransferase promoting acetylation of the transcriptional coactivator PGC-1α to control hepatic gluconeogenesis, suggesting that influencing methionines metabolic flux has the potential to be therapeutically exploited for diabetes treatment. Expand
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes
TLDR
It is shown here how CO2 transport into cells, sensing in cells and organisms, and thephysiological effects of elevated levels of CO2 on mammalian tissues and animals can be affected. Expand
Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO2-Induced Epithelial Dysfunction
TLDR
Evidence is provided that deleterious effects of hypercapnia are mediated by JNK which plays an evolutionary conserved, specific role in CO2 signaling in mammals, diptera and nematodes. Expand
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