Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.
- M. Kharel, Pallab Pahari, J. Rohr
- ChemistryNatural product reports (Print)
- 17 January 2012
The main focus of this article is on new synthetic approaches and biosynthetic investigations, most of which were published between 1997 and 2010, but go beyond, e.g. for some biosyntheses all the way back to the 1980s, to provide the necessary context of information.
Essramycin: A First Triazolopyrimidine Antibiotic Isolated from Nature†
- M. El-Gendy, M. Shaaban, K. Shaaban, A. El-Bondkly, H. Laatsch
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 March 2008
A novel triazolopyrimidine antibiotic was obtained from the culture broth of the marine Streptomyces sp.
Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties
- M. Shaaban, K. Shaaban, M. Abdel-Aziz
- ChemistryOrganic and Medicinal Chemistry Letters
- 29 February 2012
Eight bioactive pyrone derivatives were identified from the culture of Alternaria alternata strain D2006, isolated from the marine soft coral Denderonephthya hemprichi, which was selected as its…
A comprehensive review of glycosylated bacterial natural products.
- S. Elshahawi, K. Shaaban, M. Kharel, J. Thorson
- BiologyChemical Society Reviews
- 19 October 2015
This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.
Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.
- U. Hawas, M. Shaaban, H. Laatsch
- Chemistry, BiologyJournal of Natural Products
- 18 November 2009
Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.
- L. Núñez, S. E. Nybo, C. Méndez
- Chemistry, BiologyJournal of Medicinal Chemistry
- 28 June 2012
Preliminary in vivo evaluation of its antitumor activity through hollow fiber assays, and in subcutaneous colon and melanoma cancers xenografts models, suggests that demycarosyl-3D-β-d-digitoxosylmithramycin SK could be a promising antitumors agent worthy of further investigation.
Bioactive Benzopyrone Derivatives from New Recombinant Fusant of Marine Streptomyces
- M. El-Gendy, M. Shaaban, A. El-Bondkly, K. Shaaban
- Biology, ChemistryApplied Biochemistry and Biotechnology
- 13 June 2008
The fermentation, isolation, as well as the biological activity of these bioactive compounds are described here as microbial products for the first time.
Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae.
- S. Noriler, D. Savi, K. Shaaban
- BiologyFitoterapia
- 1 October 2019
Bioactive Secondary Metabolites from a New Terrestrial Streptomyces sp. TN262
- L. Elleuch, M. Shaaban, H. Laatsch
- Chemistry, BiologyApplied Biochemistry and Biotechnology
- 20 October 2009
During our search for Streptomyces spp. as new producers of bioactive secondary metabolites, the ethyl acetate extract of the new terrestrial Streptomyces isolate TN262 delivered eight…
Microbispora sp. LGMB259 Endophytic Actinomycete Isolated from Vochysia divergens (Pantanal, Brazil) Producing β-Carbolines and Indoles with Biological Activity
- D. Savi, K. Shaaban, J. Rohr
- BiologyCurrent Microbiology
- 1 March 2015
An endophytic strain isolated from the V. divergens, was investigated for its potential to show biological activity and displayed potent activity against the Gram-positive bacterial strains Micrococcus luteus NRRL B-2618 and Kocuria rosea B-1106.
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