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Positional stability of single double-strand breaks in mammalian cells
TLDR
It is demonstrated that broken ends are positionally stable and unable to roam the cell nucleus, which supports a contact-first model in which chromosome translocations predominantly form among spatially proximal DSBs.
Nitroreductase-activated nitric oxide (NO) prodrugs.
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
TLDR
Data show that Chk1 is critical for maintaining genome integrity and serves as a double-edged sword for cancer: although its inhibition kills cancer cells, it also triggers tumorigenesis when favorable mutations are accumulated for cell growth.
INDQ/NO, a bioreductively activated nitric oxide prodrug.
TLDR
Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205
TLDR
This study reveals that the nucleoporin Nup93 assisted by its interactors Nup188 and Nup205 mediates the repression of HOXA gene expression.
Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus
TLDR
A remarkable interplay between Lamin A/C and Emerin in modulating cytoskeletal organization of actin and NM1 that impinges on chromatin dynamics and function in the interphase nucleus is underscore.
Artificially Introduced Aneuploid Chromosomes Assume a Conserved Position in Colon Cancer Cells
TLDR
Using 3D-FISH and confocal laser scanning microscopy, it is shown that Chromosomes 7, 18, or 19 introduced via microcell-mediated chromosome transfer into the parental diploid colon cancer cell line DLD-1 maintain their conserved position in the interphase nucleus.
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