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Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.
TLDR
The findings suggest that the large size of a (GT)n repeat in the HO-1 gene promoter may reduceHO-1 inducibility by reactive oxygen species in cigarette smoke, thereby resulting in the development of CPE.
Increased carbon monoxide in exhaled air of asthmatic patients.
TLDR
The present study shows an elevation of exhaled CO in asthmatic patients that decreases with corticosteroid therapy, and increases in the exhaled carbon monoxide levels therefore may reflect inflammation in theAsthmatic lung.
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD.
TLDR
The ADRB2 + 79 C/G polymorphism and the haplotypes shown in this study may be involved in the pathogenesis of COPD.
Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
TLDR
It is demonstrated that Nrf2 regulates the inflammation process downstream of 15d-PGJ2 by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells.
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2).
TLDR
It is demonstrated that Nrf2 regulates the inflammation process downstream of 15d-PGJ(2) by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells.
Erythromycin and common cold in COPD.
TLDR
Erythromycin therapy has beneficial effects on the prevention of exacerbations in COPD patients, and the mean (+/- SE) number of common colds for 12 months was significantly lower in the erystromycin group than in the control group.
HIGH INCIDENCE OF ASPIRATION PNEUMONIA IN COMMUNITY‐ AND HOSPITAL‐ACQUIRED PNEUMONIA IN HOSPITALIZED PATIENTS: A MULTICENTER, PROSPECTIVE STUDY IN JAPAN
TLDR
Although the statement that plain vitamin D is the treatment of choice for vitamin D deficiency is agreed, there is no high-level evidence of which vitamin D metabolites are safer and faster in normalizing sHPTH, and more importantly, the optimal dose of vitamin D3 capable of normalizing rapidly sHP TH is still being discussed and has not been established.
Identification of polymorphisms in the promoter region of the human NRF2 gene.
TLDR
The structure of the NRF2 gene was determined and three single nucleotide polymorphisms and one triplet repeat polymorphism in its regulatory region were found, providing a molecular basis for the genetic analysis of theNRF2 genes.
High incidence of silent aspiration in elderly patients with community-acquired pneumonia.
TLDR
Scanning of the thorax demonstrated that 71% of patients aspirated, whereas aspiration was observed in only 10% of control subjects, which may indicate an important role of silent aspiration in the development of community-acquired pneumonia in the elderly.
Nrf2‐deficient mice are highly susceptible to cigarette smoke‐induced emphysema
TLDR
Results indicate that Nrf2 protects against the development of emphysema by regulating not only the oxidant/anti‐oxidant balance, but also inflammation and the protease/anti-protease balance.
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