• Publications
  • Influence
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.
Cigarette smoke, containing reactive oxygen species, is the most important risk factor for chronic pulmonary emphysema (CPE). Heme oxygenase-1 (HO-1) plays a protective role as an antioxidant in theExpand
  • 553
  • 35
Increased carbon monoxide in exhaled air of asthmatic patients.
Exhaled carbon monoxide (CO) concentrations were measured on a CO monitor by vital capacity maneuvers in asthmatic patients receiving or not receiving inhaled corticosteroids and in nonsmoking andExpand
  • 284
  • 14
  • PDF
Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
ABSTRACT Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examinedExpand
  • 327
  • 12
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2).
Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examined how Nrf2Expand
  • 157
  • 11
Polymorphisms of IL4, IL13, and ADRB2 genes in COPD.
STUDY OBJECTIVES Interleukin (IL)-4, IL-13, and beta(2)-adrenoceptor (ADRB2) are involved in airway hyperresponsiveness (AHR), and their coding genes are located on chromosome 5q31-q33. AHR is one ofExpand
  • 75
  • 11
HIGH INCIDENCE OF ASPIRATION PNEUMONIA IN COMMUNITY‐ AND HOSPITAL‐ACQUIRED PNEUMONIA IN HOSPITALIZED PATIENTS: A MULTICENTER, PROSPECTIVE STUDY IN JAPAN
point that there is no high-level evidence of which vitamin D metabolites are safer and faster in normalizing sHPTH, and more importantly, the optimal dose of vitamin D3 capable of normalizingExpand
  • 284
  • 9
Erythromycin and common cold in COPD.
STUDY OBJECTIVES To investigate whether erythromycin therapy lowers the frequency of the common cold and subsequent exacerbation in patients with COPD. DESIGN Prospective, randomized, controlled,Expand
  • 157
  • 9
  • PDF
Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure.
To partition the central and peripheral airway resistance in awake humans, a catheter-tipped micromanometer sensing lateral pressure of the airway was wedged into the right lower lobe of a 3-mm-IDExpand
  • 310
  • 7
High incidence of silent aspiration in elderly patients with community-acquired pneumonia.
Pneumonia is a major cause of death in the elderly. To investigate the role of silent aspiration in community-acquired pneumonia, we examined the occurrence of silent aspiration during sleep in 14Expand
  • 310
  • 7
Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease.
Proteinase/antiproteinase imbalance is the most widely accepted theory for development of chronic obstructive pulmonary disease (COPD). Mutations of tissue inhibitor of metalloproteinases-2 (TIMP-2)Expand
  • 116
  • 7