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Growth-Inhibitory Actions of Analogues of Luteinizing Hormone Releasing Hormone on Tumor Cells
The expression of LHRH and its receptor has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary, endometrium, and prostate. These findings suggest theExpand
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Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines.
This study was designed to elucidate the signal transduction mechanisms, mediating the antiproliferative effects of analogs of luteinizing hormone releasing hormone (LHRH) on cell lines derived fromExpand
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Strahlentherapie nach Mastektomie – Interdisziplinärer Konsensus beendet Kontroverse
Hintergrund: Die Publikationen der Danish Breast Cancer Cooperative Group und die Ergebnisse des British Columbia Trial haben zu erheblichem Diskussionsbedarf über den Stellenwert derExpand
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Androgen receptor mediated growth control of breast cancer and endometrial cancer modulated by antiandrogen- and androgen-like steroids
Androgens are involved in many regulatory processes in mammary and endometrial epithelium, but their role in the development and progression of breast and endometrial carcinoma is poorly understood.Expand
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Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation, and correlation with direct antiproliferative activity of
OBJECTIVE Several recent reports have demonstrated the expression of luteinizing hormone-releasing hormone receptors by human ovarian and endometrial cancers. Controversy persists on the relevance ofExpand
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Regulation of androgen receptor mRNA and protein level by steroid hormones in human mammary cancer cells
The regulation of the human androgen receptor (AR) by steroid hormones in human mammary cancer cells was investigated using immunocytochemical and ligand binding assays for its protein and NorthernExpand
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Clinical Breast Examination: What Can Be Recommended for Its Use to Detect Breast Cancer in Countries with Limited Resources?
Abstract: Clinical breast examination (CBE) refers to the traditional technique of physical examination of the breast by a health care provider. The examination comprises both systematic inspectionExpand
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Estrogen and androgen receptor mediated stimulation and inhibition of proliferation by androst-5-ene-3β,17β-diol in human mammary cancer cells
Abstract Androst-5-ene-3β,17β-diol (ADIOL) and 5α-adrostane-3β,17β-diol (5αA), which are metabolites of dehydroepiandrosterone and dihydrotestosterone, are known to have estrogenic properties. ThisExpand
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Medroxyprogesterone acetate inhibits the proliferation of estrogen- and progesterone-receptor negative MFM-223 human mammary cancer cells via the androgen receptor
SummaryThis study demonstrates for the first time, that medroxyprogesterone acetate (MPA) inhibits the proliferation of the estrogen and progesterone receptor negative mammary cancer cell lineExpand
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