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Biochemistry and Pharmacology of Novel Anthranilic Acid Derivatives Activating Heme-Oxidized Soluble Guanylyl Cyclase
The findings suggest that HMR1766 and S3448 preferentially activate the NO-insensitive heme-oxidized form of sGC, which exists to a variable extent in vascular tissues, and is a pharmacological target for these new vasodilator drugs.
Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans.
Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines
The oxidants potassium hexacyanoferrate, cupric sulfate, and lead tetraacetate augmented the conversion of SIN-1A to Sin-1C and increased the relaxing effect on isolated pulmonary arteries used to bioassay NO.
Heterocyclic NO prodrugs.
- K. Schönafinger
- 30 May 1999
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
Findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.
Cardiovascular actions of the furoxan CAS 1609, a novel nitric oxide donor
- H. Bohn, J. Brendel, P. Martorana, K. Schönafinger
- Biology, MedicineBritish journal of pharmacology
- 1 April 1995
Data indicate that CAS 1609 is a potent, long‐lasting orally active donor of nitric oxide, devoid of tolerance development.
Calcium- and calmodulin-antagonism of elnadipine derivatives: comparative SAR
Characterisation of furoxancarbonitriles as a new class of vasodilators.
The synthesis, structural characterization, NO-donor properties, and in vitro vasodilating activities of a series of furoxancarbonitriles 2, 17-22a, b are reported and suggest similar characteristic of in vivo NO-release.
Cardiovascular effects of the new nitric oxide donor, pirsidomine. Hemodynamic profile and tolerance studies in anesthetized and conscious dogs.
CAS 936, a Novel Sydnonimine with Direct Vasodilating and Nitric Oxide‐Donating Properties: Effects on Isolated Blood Vessels
- H. Bohn, R. Beyerle, P. Martorana, K. Schönafinger
- Biology, MedicineJournal of cardiovascular pharmacology
- 1 October 1991
The vasodilating activity of the novel sydnonimine CAS 936 in guinea pig isolated pulmonary arteries without endothelium is concluded, whereas the metabolites may function as NO donors.