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Biochemistry and Pharmacology of Novel Anthranilic Acid Derivatives Activating Heme-Oxidized Soluble Guanylyl Cyclase
TLDR
The findings suggest that HMR1766 and S3448 preferentially activate the NO-insensitive heme-oxidized form of sGC, which exists to a variable extent in vascular tissues, and is a pharmacological target for these new vasodilator drugs. Expand
Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans.
TLDR
Investigation of the molecular mode of the vasodilator action of furoxans found them to be prodrugs which increase the level of cyclic GMP via formation of NO and may therefore be classified as nitrovasodilators. Expand
Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines
TLDR
The oxidants potassium hexacyanoferrate, cupric sulfate, and lead tetraacetate augmented the conversion of SIN-1A to Sin-1C and increased the relaxing effect on isolated pulmonary arteries used to bioassay NO. Expand
Heterocyclic NO prodrugs.
TLDR
An overview of the different heterocyclic NO-releasing compounds is given: sydnone imines need oxidants like oxygen, furoxanes are converted to NO via reaction with thioles, and each class of compounds requires different cofactors for NO release. Expand
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
TLDR
Findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes. Expand
Cardiovascular actions of the furoxan CAS 1609, a novel nitric oxide donor
TLDR
Data indicate that CAS 1609 is a potent, long‐lasting orally active donor of nitric oxide, devoid of tolerance development. Expand
Calcium- and calmodulin-antagonism of elnadipine derivatives: comparative SAR
Abstract The Ca 2+ -antagonistic properties of elnadipine derivatives have been quantified by means of binding experiments in bovine cerebral cortex membranes using 3 H-nitrendipine. CompetitionExpand
Characterisation of furoxancarbonitriles as a new class of vasodilators.
TLDR
The synthesis, structural characterization, NO-donor properties, and in vitro vasodilating activities of a series of furoxancarbonitriles 2, 17-22a, b are reported and suggest similar characteristic of in vivo NO-release. Expand
Cardiovascular effects of the new nitric oxide donor, pirsidomine. Hemodynamic profile and tolerance studies in anesthetized and conscious dogs.
TLDR
The results indicate that pirsidomine possesses an antianginal hemodynamic profile similar to that of its main metabolite, M1, and of IS-5-MN, which suggests a common mode of action via the release of NO. Expand
CAS 936, a Novel Sydnonimine with Direct Vasodilating and Nitric Oxide‐Donating Properties: Effects on Isolated Blood Vessels
TLDR
The vasodilating activity of the novel sydnonimine CAS 936 in guinea pig isolated pulmonary arteries without endothelium is concluded, whereas the metabolites may function as NO donors. Expand
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