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The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase.
  • Y. Liu, Y. Zhang, +8 authors J. Shyy
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 November 2005
We previously reported that laminar flow activates peroxisome proliferator-activated receptor gamma (PPARgamma) in vascular endothelial cells in a ligand-dependent manner that involves phospholipaseExpand
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Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry.
Cyclooxygenase, lipoxygenase, and epoxygenase derived oxylipins, especially eicosanoids, play important roles in many physiological processes. Assessment of oxidized fatty acid levels is importantExpand
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Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear. Herein, we report the presence,Expand
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Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor
We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics.Expand
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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
A series of potent and selective [1,2,4]triazolo[1,5-a]pyrimidine PDE2a inhibitors is reported. The design and improvement of the binding properties of this series was achieved using X-ray crystalExpand
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The lipid maps initiative in lipidomics.
The Lipid Metabolites and Pathways Strategy (LIPID MAPS) initiative constitutes the first broad scale national exploration of lipidomics and is supported by a U.S. National Institute of GeneralExpand
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Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
We report the first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541Expand
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Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
A series of potent thienotriazolopyrimidinone-based PDE1 inhibitors was discovered. X-ray crystal structures of example compounds from this series in complex with the catalytic domain of PDE1B andExpand
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Identification and characterization of novel small molecule Protease Activated Receptor 2 ( PAR 2 ) agonists
243 words Introduction: 708 words Discussion: 1137 words