K. Scharffetter-Kochanek

Publications385
h-index65
Citations15,279
Highly Influential Citations465
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Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice
A null mutation was prepared in the mouse for CD18, the β2 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions. The… Expand
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Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events.
Effects of sunlight have fascinated researchers for decades because nearly every living thing on earth is likely to be exposed to sunlight and the ultraviolet (UV) fraction of it. In addition to… Expand
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Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
The decline in hematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of… Expand
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An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
Uncontrolled macrophage activation is now considered to be a critical event in the pathogenesis of chronic inflammatory diseases such as atherosclerosis, multiple sclerosis, and chronic venous leg… Expand
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Solar UV irradiation and dermal photoaging.
The skin is increasingly exposed to ambient UV-irradiation thus increasing risks for photooxidative damage with long-term detrimental effects like photoaging, characterized by wrinkles, loss of skin… Expand
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Photoaging of the skin from phenotype to mechanisms
The skin is increasingly exposed to ambient UV-irradiation thus increasing its risk for photooxidative damage with longterm detrimental effects like photoaging, which is characterized by wrinkles,… Expand
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A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
Many organs with a high cell turnover (for example, skin, intestine and blood) are composed of short-lived cells that require continuous replenishment by somatic stem cells. Ageing results in the… Expand
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TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds.
Proper activation of macrophages (Mφ) in the inflammatory phase of acute wound healing is essential for physiological tissue repair. However, there is a strong indication that robust Mφ inflammatory… Expand
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Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine hematopoietic Sca-1+/Lin−… Expand
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A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice.
Previously, a hypomorphic mutation in CD18 was generated by gene targeting, with homozygous mice displaying increased circulating neutrophil counts, defects in the response to chemically induced… Expand
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