• Publications
  • Influence
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells.
Cisplatin can increase the availability of the reduced folate necessary for tight binding of FdUMP to dTMP synthase, thus enhancing the cytotoxicity of the cisplatin and 5FUra combination. Expand
Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.
A role is established for c-fos in drug resistance and in mediating DNA synthesis and repair processes by modulating expression of genes such as dTMP synthase, DNA polymerase beta, and topoisomerase I. Expand
Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid.
The molecular and biochemical properties of cisplatin-resistant A2780 cells were analyzed for changes in the dTMP synthase cycle, and data would suggest that cis platin resistance is associated with changes in folate metabolism. Expand
The Promised Land
‘This is the land of which I swore to give Abraham, Isaac, and Jacob, saying, ‘I will give it to your descendants.’ I have caused you to see it with your eyes, but you shall not cross overExpand
Cisplatin resistance in human cancers.
The c-fos proto-oncogene, a master switch for turning on other genes in response to a wide range of stimuli, has been shown to play an important role in cisplatin resistance both in vitro and in patients. Expand
Oligonucleotide‐mediated modulation of mammalian gene expression 1
The current knowledge in this field of oligonucleotide‐mediated modulation of mammalian gene expression is discussed, focusing on the biology of triplex DNA, antisense oligon nucleotides, and ribozymes. Expand
Altered expression of mRNAs for apoptosis‐modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA
Overexpression of the pro‐apoptotic bcl‐xS gene in the DLKP‐SQ/10p line partially reversed resistance not only to P‐gp‐associated drugs but also to 5‐fluorouracil, indicating that the ratio of bcl family members may be important in determining sensitivity to chemotherapeutic drug‐induced apoptosis. Expand
Application of ribozymes to cancer gene therapy.
Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells.
The data suggest that the initial step of cisplatin resistance in A2780 cells is a consequence of enhanced expression of the thymidylate synthase cycle, and this increase did not result from amplification of the genes for these two enzymes. Expand
Oligonucleotides as modulators of cancer gene expression.
This review describes how these different oligonucleotides can be used to define gene function and discusses in detail their chemical structure, mechanism of action, advantages and disadvantages, and their applications. Expand