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Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: A multicenter study
Active ulcerative colitis (UC) is characterized by activation and infiltration of granulocytes and monocytes/macrophages into the colonic mucosa. The infiltrated leukocytes can cause mucosal damageExpand
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Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column.
The administration of steroids is not always effective for the treatment of ulcerative colitis (UC). Their long-term use often causes adverse effects which sometimes result in their stoppage andExpand
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Leukocytapheresis therapy, performed with leukocyte removal filter, for inflammatory bowel disease
Leukocytapheresis (LCAP), performed with a leukocyte removal filter, was administered five times, at 1-week intervals, for 5 weeks of intensive therapy and five times, at approximately 1-monthExpand
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Hepatitis B virus carriers in the treatment of malignant lymphoma: an epidemiological study in Japan.
BACKGROUND Hepatitis B after the withdrawal of cytotoxic chemotherapy in hepatitis B virus (HBV) carriers is well known and may lead to fatal hepatic failure. We retrospectively analyzed theExpand
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Therapeutic leukocytapheresis for inflammatory bowel disease.
The inference that granulocytes and monocytes/macrophages (GM) are part of the immunopathogenesis of inflammatory bowel disease (IBD) and hence should be targets of therapy stems from observations ofExpand
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Leukocytapheresis as an Adjunct to Conventional Medication for Inflammatory Bowel Disease
  • K. Sawada
  • Medicine
  • Diseases of the colon and rectum
  • 1 October 2003
Inflammatory bowel disease is characterized by clinical remission and relapse caused by severe intestinal inflammation. Drug therapy for inflammatory bowel disease is associated with unpleasant sideExpand
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Adacolumn for selective leukocytapheresis as a non‐pharmacological treatment for patients with disorders of the immune system: An adjunct or an alternative to drug therapy?
Inflammatory and/or autoimmune diseases like ulcerative colitis (UC) or Crohn's disease (CD) are debilitating chronic disorders that poorly respond to pharmacological interventions. Further, drugExpand
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Adsorptive granulocyte and monocyte apheresis for refractory Crohn’s disease: an open multicenter prospective study
BackgroundActive Crohn’s disease (CD) is often associated with elevated levels of platelets, granulocytes, and monocytes that are activated and resistant to apoptosis. The level of neutrophils in theExpand
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Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs.
Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitatingExpand
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Granulocyte Adsorptive Apheresis for Pediatric Patients with Ulcerative Colitis
Granulocytapheresis (GCAP) has produced efficacy in adult patients with ulcerative colitis (UC) by adsorbing activated granulocytes and monocytes/macrophages. We retrospectively investigated efficacyExpand
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