• Publications
  • Influence
Synthesis of a key intermediate of levofloxacin via enantioselective hydrogenation catalyzed by iridium(I) complexes
Abstract The key intermediate 2 for the antibacterial agent levofloxacin 1 was prepared by utilizing catalytic asymmetric hydrogenation of the cyclic imine 3 with the iridium(I) complex of (2 S ,4 S
Use of polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis to detect a point mutation in the catalase-peroxidase gene (katG) ofMycobacterium tuberculosis
TLDR
The described PCR-SSCP is a reliable method for screening M. tuberculosis strains for the katG R463L mutation and is in complete agreement with the PCR- Msp I RFLP reference method.
Reversible Helix−Helix Transition of Poly(β-phenylpropyl l-aspartate) Involving a Screw-Sense Inversion in the Solid State
Poly(β-phenylpropyl l-aspartate) exhibits a novel helix−helix transition in the solid state at around 160 °C. The transition takes place reversibly in a narrow temperature range during a heating and
Efficient ester exchange reaction of phosphonoacetates
Abstract A novel method for the preparation of differentially substituted phosphonoacetates and phosphonoacetamides using 4-DMAP catalyzed ester exchange reaction has been developed.
Efficient synthesis of a key intermediate of DV-7751 via optical resolution or microbial reduction.
Two efficient and practical methods of synthesis of the C-10 substituent of DV-7751 (1), a novel quinolone carboxylic acid, were established. The first method utilizes an optical resolution of
Use of polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis to detect a point mutation in the catalase-peroxidase gene (katG) of Mycobacterium tuberculosis.
TLDR
It is concluded that the described PCR-SSCP is a reliable method for screening M. tuberculosis strains for the katG R463L mutation.
Effects of various thiol molecules added on morphology of dendrimer-gold nanocomposites.
TLDR
The mechanisms for morphology changes in the dendrimer-gold nanocomposites by the addition of these thiols are discussed and the average particle size was seen only when the combination of PAMAM-gold Nanocomposite and thiol-modified dendron was less sterically dense, modified dendrons.
Red-Al promoted intramolecular reductive cleavage of benzyl 4-hydroxy-2-butenyl ether structures. A concise preparation of polyol chiral building blocks
Abstract A new concise and practical method for the preparation of polyol chiral building blocks has been developed based on the finding of unprecedented Red-Al promoted intramolecular reductive
An Efficient Synthesis of a Key Intermediate of DU-6859a via Asymmetric Microbial Reduction
An efficient synthesis method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial
...
1
2
3
...