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PHARMACOLOGICAL PROFILE OF A NEW CORONARY VASODILATOR DRUG, 2‐NICOTINAMIDOETHYL NITRATE (SG‐75)
1. In anaesthetized, open‐chest dogs, 2‐nicotinamidoethyl nitrate (SG‐75) administered intravenously (0.3–1 mg/kg) or intraduodenally (3 mg/kg) produced decreases in systemic blood pressure, coronaryExpand
Circumstantial evidence for increased potassium conductance of membrane of cardiac muscle by 2-nicotinamidoethyl nitrate (SG-75).
TLDR
The results indicate that the cardiac action ofSG-75 differs from that of calcium-antagonistic vasodilators and it is suggested that the basic mechanism of action of SG-75 involves an increase in potassium conductance in the membrane of cardiac muscle, without mediation through muscarinic receptors. Expand
Mode and mechanism of action of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, on the dog heart.
TLDR
In heart-lung preparations OPC -8212 improved cardiac function depressed with pentobarbital, and caused bradycardia, and in trabecular muscles of the right ventricle OPC-8212 produced a concentration-dependent positive inotropic effect in the presence of the beta 1-adrenoceptor antagonist, atenolol. Expand
Coronary Vasodilator and Cardiac Effects of Optical Isomers of Verapamil in the Dog
TLDR
Results indicate that in equieffective doses in producing coronary vasodilatation (+) verapamil is far less cardiodepressant than the (-) isomer. Expand
Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog
TLDR
The results suggest that the vasorelaxant effect of FK409, like that of nitroglycerin, is due to activation of soluble guanylate cyclase and a resultant increase in intracellular cyclic GMP. Expand
Selectivity of alinidine, a bradycardic agent, for SA nodal automaticity versus other cardiac activities in isolated, blood-perfused dog-heart preparations.
TLDR
The cardiac effects of alinidine were longer-lasting than its vascular effect and the reduction of sinus rate was particularly long-lasting, which is different from that of AQ-A 39, another bradycardic agent, which was nearly equi-effective on both SA nodal and ventricular automaticity. Expand
Are the cardiovascular effects of gentamicin similar to those of calcium antagonists?
TLDR
Cardiac and coronary vasodilator effects of gentamicin were investigated in isolated, blood-perfused papillary muscle, sino-atrial (SA) node and atrioventricular (AV) node preparations of dogs, finding a cardiovascular profile similar to that of manganese ions, reflecting its own mechanism of action. Expand
A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart
TLDR
It is indicated that both nicorandil and SG-209 act as K-channel openers in coronary resistance vessels and in ventricular myocardium, and that the nitroxyl and the acetoxyl group at C2 of the parent structure of nicor andil and its congeners play a pivotal role in making these compounds act asK- channel openers. Expand
α2‐Adrenoceptors and endothelium‐dependent relaxation in canine large arteries
TLDR
It is concluded that endothelium‐dependent relaxation to NA and substance P varies greatly across 5 large arteries of the dog, which may indicate that endotHelium‐derived relaxing factor (EDRF) release is site‐dependent or that the efficacy of EDRF on smooth muscle varies. Expand
NO EFFECT OF ATRIAL NATRIURETIC FACTOR ON CARDIAC RATE, FORCE AND TRANSMITTER RELEASE
1. The effects of atrial natriuretic factor (ANF, 1‐300 nmol/l) on cardiac rate, force and neurotransmitter release were examined in guinea‐pig isolated heart preparations.
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