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CYP2A6 gene deletion reduces susceptibility to lung cancer.
CYP2A6 is an enzyme with a high ability to activate a nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to its potent and ultimate carcinogen. In the present study, we investigatedExpand
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Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery.
Erythropoietin (EPO) prevents the ischemia-induced delayed neuronal death in the hippocampal CA1 field in gerbils. EPO receptor (EPOR) is also expressed in the cerebral cortex but its function is notExpand
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Characterization of glycogen phosphorylase isoenzymes present in cultured skeletal muscle from patients with McArdle's disease.
Abstract Muscle biopsy specimens from patients with McArdle's disease lack glycogen phosphorylase activity. Significant phosphorylase activity was detected in cultured muscle cells from theseExpand
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Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life.
Obtusifoliol 14alpha-demethylase is a plant orthologue of sterol 14alpha-demethylase (CYP51) essential in sterol biosynthesis. We have prepared CYP51 antisense Arabidopsis in order to shed light onExpand
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Drug resistance to cis-diamminedichloroplatinum (II) in Chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene.
Establishment of Chinese hamster ovary (CHO) cell lines expressing human glutathione S-transferase-pi (GST-pi) was performed after cotransfection of pSV2-neo and human GST-pi cDNA-carrying plasmid pExpand
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Human BST-1 expressed on myeloid cells functions as a receptor molecule.
We have previously identified and cloned BST-1 as a molecule which is overexpressed on the bone marrow stromal cell lines derived from patients with rheumatoid arthritis and which has the ability toExpand
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Apamin-sensitive Ca2+-dependent K+ current and hyperpolarization in human endothelial cells.
Vascular endothelial cells have several types of Ca2+-dependent K+ current (I(K-Ca)). Here, we describe apamin-sensitive I(K-Ca) which is activated by treatment with histamine (His) in humanExpand
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Identification of a novel human ankyrin-repeated protein homologous to CARP.
We cloned a novel ankyrin repeat protein, Arpp, by immunoscreening a cDNA library constructed from a human esophageal carcinoma cell line, TE1, with an antibody directed to a hypothetical proteinExpand
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Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase.
Evidence is presented that a distinctive type of glutathione-S-transferase (GSHTase-P), and a cytosolic polypeptide of Mr 52,000 (P-52), each appearing in greatly increased amounts in hepatocyteExpand
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Hepatocyte nuclear factor 3beta participates in the transcriptional regulation of the thyroperoxidase promoter.
The promoters of the thyroglobulin (Tg) and thyroperoxidase (TPO) genes both contain sequences that match the consensus recognized by the fork-head family of transcription factors. The fork-headExpand
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