K. Sasaki

Publications90
h-index23
Citations1,601
Highly Influential Citations38
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Crystal structure of measles virus hemagglutinin provides insight into effective vaccines
TLDR
It is suggested that sugar moieties in the MV hemagglutinin critically modulate virus–receptor interaction as well as antiviral antibody responses, differently from sugars of the HIV gp120, which allow for immune evasion.
Structural basis of the 3′‐end recognition of a leading strand in stalled replication forks by PriA
TLDR
The crystal structures in complexes with oligonucleotides and the combination of fluorescence correlation spectroscopy and mutagenesis reveal that the N‐terminal domain of PriA possesses a binding pocket for the 3′‐ terminal nucleotide residue of DNA, prerequisite for the proper positioning of the helicase domain ofPriA on the unreplicated double‐stranded DNA.
Escherichia coli PriA Protein, Two Modes of DNA Binding and Activation of ATP Hydrolysis*
TLDR
It is shown here that PriA binds to DNA in a manner either dependent on or independent of 3′ terminus recognition, and ATP hydrolysis activity of PriA can be stimulated in vitro by either of the two binding modes.
Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549.
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.
Enzymatic Characterization of Human α1,3-Fucosyltransferase Fuc-TVII Synthesized in a B Cell Lymphoma Cell Line*
TLDR
Fuc-TVII was demonstrated to be useful for the synthesis of a sialyl Lewis x hexasaccharide from lacto-N-neotetraose in combination with an α2,3-sialyltransferase, ST3Gal IV, and its inhibitory effects of various nucleotides on the activity reflected its donor specificity for the nucleotide portion of GDP.
Transcriptional regulation of human polo-like kinases and early mitotic inhibitor.
Synthesis of Calcium Silicate Hydrate with Ca/Si = 2 by Mechanochemical Treatment
An amorphous, C-S-H-like phase with Ca/Si = 2 was synthesized from amorphous precipitated silica, calcium oxide, and water by mechanochemical treatment using a vibration mill at room temperature. The…
An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism*
TLDR
A small molecule GK activator, compound A, was identified that increased the glucose affinity and maximal velocity of GK and found that glucose-dependent GK-GKRP interaction also required ATP.
Phase Evolution during Autoclaving Process of Aerated Concrete
The reactions were investigated that occur when lime, cement, and quartz sand are mixed together and molded, then treated at 180°C under saturated steam pressures to produce autoclaved aerated…
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