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pH- and ion-sensitive polymers for drug delivery
Introduction: Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS forExpand
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Scintigraphic evaluation of a novel colon-targeted delivery system (CODES) in healthy volunteers.
The purposes of this study are to investigate the gastrointestinal transit and release properties of a novel, colon-targeted delivery system (CODES) administered to healthy volunteers using gammaExpand
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Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets.
The purpose of this study was to evaluate the feasibility of using a counter polymer in polyethylene oxide (PEO)/polyethylene glycol (PEG) polymeric matrices for the sustained release of a largeExpand
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Polymer combination increased both physical stability and oral absorption of solid dispersions containing a low glass transition temperature drug: physicochemical characterization and in vivo study.
The purpose of this study was establishing a solid dispersion formulation containing a low glass transition temperature (T(g)) and poorly water-soluble drug. Drug/polymer blends with differingExpand
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Relationship Between Gelation Rate of Controlled-release Acetaminophen Tablets Containing Polyethylene Oxide and Colonic Drug Release in Dogs
AbstractPurpose. We hypothesized that sufficient gelation of orally administered hydrophilic matrix tablets before they reach the colon could, as a result of continuous erosion of the gelated matrix,Expand
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Effects of absorption promoters on insulin absorption through colon-targeted delivery.
The aim of this study were to investigate the effect of sodium glycocholate (GC-Na) as an absorption promoter and the effects of the co-administration of GC-Na and various absorption promoters onExpand
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Influence of physical factors in gastrointestinal tract on acetaminophen release from controlled-release tablets in fasted dogs
Abstract Four types of controlled-release (CR) acetaminophen (AAP) tablets, namely A, B, C and D, were prepared to investigate the influence of physical factors in the gastrointestinal (GI) tract onExpand
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Assessment of tacrolimus absorption from the human intestinal tract: open-label, randomized, 4-way crossover study.
BACKGROUND Tacrolimus is an established immunosuppressant used for the prevention and treatment of allograft rejection in solid organ transplantation. An immediate-release oral formulation ofExpand
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Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: Evaluation of solid dispersion formulations.
The aim of this study was to investigate the effect of Eudragit E/HCl (E-SD) on the reprecipitation of a poorly water-soluble drug, tacrolimus. To evaluate the inhibition of reprecipitation of E-SD,Expand
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Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy.
Compression-coated time-release tablets (CC tablets) containing nifedipine, dihydropyridine Ca channel blocker, in the core tablet were prepared by dry coating with different polyethyleneExpand
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