K. Sakai

Publications113
h-index46
Citations7,447
Highly Influential Citations185
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Neuronal Activity of Histaminergic Tuberomammillary Neurons During Wake–Sleep States in the Mouse
TLDR
The view that the activity of histaminergic tuberomammillary neurons plays an important role, not in the induction of wakefulness per se, but in the maintenance of the high level of vigilance necessary for cognitive processes is supported.
Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat
TLDR
It is hypothesized that the histaminergic descending afferents in the MPT would promote cortical desynchronization and W, at least partially, via activation of H1 receptors situated on cholinergic neurons and that the interactions between Histaminergic and cholin allergic neurons constitute an important circuit in cortical activation during W.
Executive mechanisms of paradoxical sleep.
  • K. Sakai
  • Psychology, Medicine
    Archives italiennes de biologie
  • 10 January 1988
Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake–sleep states
TLDR
It is suggested that presumed serotonergic dorsal raphe neurons play different roles in behavioral state control and that there is functional topographic organization in the dorsal rape nucleus.
A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats
TLDR
The present data support the hypotheses that the posterior hypothalamus plays a critical role in the mechanisms of W and that sleep might result from functional blockade of the hypothalamic waking center.
Locus coeruleus neuronal activity during the sleep-waking cycle in mice
TLDR
Findings support the previous view that the NA-LC system is involved in both tonic and phasic processes of arousal, and further support proposals that initiation of sleep is caused by decreased activity of waking-promoting neurons (disfacilitation) and that NA- LC neurons play an important role in the sleep/waking switch.
Sleep-waking discharge profiles of dorsal raphe nucleus neurons in mice
  • K. Sakai
  • Medicine, Chemistry
    Neuroscience
  • 1 December 2011
TLDR
The present study shows a marked heterogeneity and functional topographic organization of both serotonergic and non-serotonergic mouse DR neurons and suggests that they play different roles in behavioral state control and the sleep/waking switch.
Evidence for histaminergic arousal mechanisms in the hypothalamus of cat
TLDR
The results suggest that histaminergic systems in the hypothalamus play an important role in arousal mechanisms and their actions are mediated through H1-receptors.
Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat
TLDR
The findings support the hypothesis that the histaminergic neurons are critically involved in arousal mechanisms and suggest that H3-receptors play an active part in these mechanisms by regulating histamine transmission.
Tegmentoreticular projections with special reference to the muscular atonia during paradoxical sleep in the cat: An HRP study
TLDR
Attempts were made to determine the cells of origin and the descending pathway of the tegmentoreticular projections in order to give an anatomical substrate for the physiological phenomenon of the postural atonia observed during paradoxical sleep in the cat.
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