Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
- J. Hanna, A. Cheng, +7 authors R. Jaenisch
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 4 May 2010
Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human… Expand
Direct cell reprogramming is a stochastic process amenable to acceleration
- J. Hanna, K. Saha, +5 authors R. Jaenisch
- Biology, Medicine
- Nature
- 29 October 2009
Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor… Expand
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
- J. Hanna, K. Saha, R. Jaenisch
- Biology, Medicine
- Cell
- 1 November 2010
Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of… Expand
Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells
- Ying Mei, K. Saha, +13 authors D. Anderson
- Biology, Medicine
- Nature materials
- 1 August 2010
Both human embryonic stem (hES) cells and induced pluripotent stem (hiPS) cells can self-renew indefinitely in culture, however current methods to clonally grow them are inefficient and… Expand
Technical challenges in using human induced pluripotent stem cells to model disease.
- K. Saha, R. Jaenisch
- Biology, Medicine
- Cell stem cell
- 4 December 2009
Reprogramming of human somatic cells uses readily accessible tissue, such as skin or blood, to generate embryonic-like induced pluripotent stem cells (iPSCs). This procedure has been applied to… Expand
Crispr democracy: Gene editing and the need for inclusive deliberation
- S. Jasanoff, J. Hurlbut, K. Saha
- Political Science
- 2015
Not since the early, heady days of recombinant DNA (rDNA) has a technique of molecular biology so gripped the scientific imagination as the CRISPR-Cas9 method of gene editing. Its promises are… Expand
- 80
- 4
- PDF
Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing
- Jared Carlson-Stevermer, Amr A Abdeen, +4 authors K. Saha
- Biology, Medicine
- Nature Communications
- 23 November 2017
Writing specific DNA sequences into the human genome is challenging with non-viral gene-editing reagents, since most of the edited sequences contain various imprecise insertions or deletions. We… Expand
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions
- K. Saha, Ying Mei, +8 authors R. Jaenisch
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 7 November 2011
The current gold standard for the culture of human pluripotent stem cells requires the use of a feeder layer of cells. Here, we develop a spatially defined culture system based on UV/ozone radiation… Expand
Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells
- M. Li, Huashan Zhao, +6 authors X. Zhao
- Biology, Medicine
- Stem cells
- 1 January 2017
Human patient‐derived induced pluripotent stem cells (hiPSCs) provide unique opportunities for disease modeling and drug development. However, adapting hiPSCs or their differentiated progenies to… Expand
Research ethics: Treat donors as partners in biobank research
- K. Saha, J. Hurlbut
- Political Science, Medicine
- Nature
- 20 October 2011
Proposed rules to protect research subjects will impede progress, say Krishanu Saha and J. Benjamin Hurlbut. Instead, give donors more say in how samples are used.