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Apoptosis induction by epigallocatechin gallate involves its binding to Fas.
TLDR
The results suggest that EGCG-binding to Fas, presumably on the cell surface, triggers the Fas-mediated apoptosis in U937 cells. Expand
Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity.
TLDR
Data suggest the important role of the 5'(3')-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds. Expand
Tea catechins and related polyphenols as anti-cancer agents.
Epigallocatechin gallate (EGCg) and theaflavins, a major constituent of green tea infusion and the constituents of black tea, respectively, were found to inhibit matrix metalloproteinases (MMPs)Expand
Apoptosis-inducing Activity of High Molecular Weight Fractions of Tea Extracts
TLDR
High molecular weight fractions of green tea, black tea, oolong tea, and pu-erh tea were found to induce apoptosis in human monoblastic leukemia U937 cells and their apoptosis-inducing activity may contribute to cancer chemopreventive effects of tea. Expand
Inhibition of Matrix Metalloproteinases by Tea Catechins and Related Polyphenols
TLDR
The results suggest that previously observed inhibition of metastasis by green tea infusion can be explained at least partly by inhibition by tea catechins of MMPs the activities of which are necessary for tumor cell invasion. Expand
Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells.
TLDR
Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. Expand
Apoptosis-inducing activity of galloyl monosaccharides in human histiocytic lymphoma U937 cells.
TLDR
Three galloyl monosaccharides contained in medicinal plants were examined for apoptosis-inducing activity in human histiocytic lymphoma cells, and TgG induced apoptosis in human colon and stomach cancer cell lines, indicating it is potentially useful as an anti-cancer agent. Expand
Apoptosis-inducing Activity of a Driselase Digest Fraction of Green Tea Residue
TLDR
A fraction of the digest soluble in 70% ethanol was found to induce the death of U937 human histiocytic lymphoma cells by apoptosis, and the green tea residue may be a useful source of potential agents with anti-cancer activity. Expand
Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells.
TLDR
Results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells. Expand
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