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Antifolates can have a role in the treatment of Plasmodium vivax.
TLDR
Data indicate that, under certain circumstances, SP could be a valuable tool in the fight against P. vivax. Expand
Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
TLDR
It was found that the P. vivax dhfr coding region and its flanking intergenic regions are highly polymorphic and that mutations in P. pyrimethamine-resistance conferring mutations that confer antifolate resistance have arisen several times in the Asian region. Expand
Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand.
TLDR
The highly mutant allele combination was especially prevalent along the Thai-Myanmar border, whereas the majority of the isolates from areas along the Thailand-Cambodian and Thai-Malaysian borders carried double mutant alleles of pvdhfr and single mutant allels of pVDhps. Expand
Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand
TLDR
In Thailand, the high levels of CQ pressure have led to strong selection of the pfcrt 76T polymorphism and pfmdr1 86N appears to be a good predictor of in vitro MF resistance. Expand
The identities and anti-herpes simplex virus activity of Clinacanthus nutans and Clinacanthus siamensis.
TLDR
The combination of macroscopic, microscopic and biomolecular method are able to authenticate these closely related plants and both of them have a potency to be an anti-HSV agent. Expand
Plasmodium falciparum: gene mutations and amplification of dihydrofolate reductase genes in parasites grown in vitro in presence of pyrimethamine.
TLDR
It is concluded that whereas some mutations producing changes in the amino acid sequence of the DHFR molecule may occur occasionally in clones or populations of P. falciparum grown in vitro in the presence of pyrimethamine, amplification of theDHFR gene following adaptation to growth in medium containing pyrimEThamine occurs as a regular feature. Expand
Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand.
TLDR
Results suggest that quadruple mutant alleles confer decreased sensitivity to pyrimethamine but retain sensitivity to WR99210. Expand
Plasmodium vivax Drug Resistance Genes; Pvmdr1 and Pvcrt-o Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand
TLDR
The results suggest that chloroquine resistance gene is now spreading in this area along the Thai-Myanmar border in Mae Sot district of Thailand, and monitoring ofchloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria. Expand
Genotyping of polymorphic marker (MSP3α and MSP3β) genes of Plasmodium vivax field isolates from malaria endemic of Thailand
TLDR
Results strongly support that P. vivax isolates in Thailand are markedly diverse, and PCR/RFLP provides a powerful method for genotyping and identification of mixed parasite infections without requirement of gene sequencing. Expand
Monitoring of clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine in area along Thai Myanmar border during 2009-2010
TLDR
In vivo results suggest that the standard regimen of chloroquine was still very effective for the treatment of blood infections with P. vivax in the Thai-Myanmar border area, and in vitro sensitivity data raise the possibility of potential advent of resistance in the future. Expand
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