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The human genome browser at UCSC.
As vertebrate genome sequences near completion and research refocuses to their analysis, the issue of effective genome annotation display becomes critical. A mature web tool for rapid and reliable… Expand
The UCSC Table Browser data retrieval tool
The University of California Santa Cruz (UCSC) Table Browser (http://genome.ucsc.edu/cgi-bin/hgText) provides text-based access to a large collection of genome assemblies and annotation data stored in the Genome Browser Database. Expand
The UCSC Genome Browser Database
The University of California Santa Cruz (UCSC) Genome Browser Database is an up to date source for genome sequence data integrated with a large collection of related annotations. Expand
Initial sequencing and comparative analysis of the mouse genome.
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an… Expand
Aligning multiple genomic sequences with the threaded blockset aligner.
We define a "threaded blockset," which is a novel generalization of the classic notion of a multiple alignment. A new computer program called TBA (for "threaded blockset aligner") builds a threaded… Expand
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome… Expand
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
- R. Myers, J. Stamatoyannopoulos, +311 authors Brian A. Risk
- Biology, Medicine
- PLoS biology
- 1 April 2011
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology… Expand
Comparative recombination rates in the rat, mouse, and human genomes.
Levels of recombination vary among species, among chromosomes within species, and among regions within chromosomes in mammals. This heterogeneity may affect levels of diversity, efficiency of… Expand
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected… Expand
Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution.
Six measures of evolutionary change in the human genome were studied, three derived from the aligned human and mouse genomes in conjunction with the Mouse Genome Sequencing Consortium, consisting of… Expand