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Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence.
- K. Roland, L. Martin, C. R. Esther, J. Spitznagel
- Biology, Medicine
- Journal of bacteriology
- 1 July 1993
We isolated spontaneous mutations (pmrA) in the smooth strain Salmonella typhimurium LT2 that show increased resistance to the cationic antibacterial proteins of human neutrophils and to the drug… Expand
Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment
- W. Kong, Soo-Young Wanda, +4 authors R. Curtiss
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 July 2008
We have devised and constructed a biological containment system designed to cause programmed bacterial cell lysis with no survivors. We have validated this system, using Salmonella enterica serovar… Expand
Construction and evaluation of a delta cya delta crp Salmonella typhimurium strain expressing avian pathogenic Escherichia coli O78 LPS as a vaccine to prevent airsacculitis in chickens.
- K. Roland, R. Curtiss, D. Sizemore
- Biology, Medicine
- Avian diseases
- 1 July 1999
Avian pathogenic strains of Escherichia coli cause a number of extraintestinal diseases in poultry, including airsacculitis and colisepticemia. Expression of O78 lipopolysaccharide (LPS) is… Expand
Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium
- Qingke Kong, J. Yang, Q. Liu, P. Alamuri, K. Roland, R. Curtiss
- Biology, Medicine
- Infection and Immunity
- 18 July 2011
ABSTRACT Lipopolysaccharide (LPS) is a major virulence factor of Salmonella enterica serovar Typhimurium and is composed of lipid A, core oligosaccharide (C-OS), and O-antigen polysaccharide (O-PS).… Expand
Immunization with Salmonella enterica Serovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge with Streptococcus pneumoniae
- Maneesha Muralinath, M. Kuehn, K. Roland, R. Curtiss
- Biology, Medicine
- Infection and Immunity
- 29 November 2010
ABSTRACT Gram-negative bacteria produce outer membrane vesicles (OMVs) that serve a variety of functions related to survival and pathogenicity. Periplasmic and outer membrane proteins are naturally… Expand
Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity.
- Y. Jiang, Qingke Kong, K. Roland, R. Curtiss
- Biology, Medicine
- International journal of medical microbiology…
- 1 May 2014
Vesicle shedding from bacteria is a universal process in most Gram-negative bacteria and a few Gram-positive bacteria. In this report, we isolate extracellular membrane vesicles (MVs) from the… Expand
Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection
- J. Yang, Jennifer Barrila, +4 authors C. Nickerson
- Biology, Medicine
- PLoS neglected tropical diseases
- 1 June 2015
A distinct pathovar of Salmonella enterica serovar Typhimurium, ST313, has emerged in sub-Saharan Africa as a major cause of fatal bacteremia in young children and HIV-infected adults. D23580, a… Expand
Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA
- Y. Li, S. Wang, +5 authors R. Curtiss
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 13 January 2009
Increasing the immunogenicity to delivered antigens by recombinant attenuated Salmonella vaccines (RASV) has been the subject of intensive study. With this goal in mind, we have designed and… Expand
Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium.
- C. Baek, S. Wang, K. Roland, R. Curtiss
- Biology, Medicine
- Journal of bacteriology
- 15 February 2009
Leucine-responsive regulatory protein (Lrp) is a global gene regulator that influences expression of a large number of genes including virulence-related genes in Escherichia coli and Salmonella. No… Expand
The Campylobacter jejuni Dps Homologue Is Important for In Vitro Biofilm Formation and Cecal Colonization of Poultry and May Serve as a Protective Antigen for Vaccination
- James R. Theoret, K. Cooper, +4 authors L. Joens
- Biology, Medicine
- Clinical and Vaccine Immunology
- 11 July 2012
ABSTRACT In this work, we investigated the Campylobacter jejuni dps (DNA binding protein from starved cells) gene for a role in biofilm formation and cecal colonization in poultry. In vitro biofilm… Expand
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