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Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence
DNA sequence analysis of the pmrA505 clone revealed three open reading frames (ORFs) and deduced amino acid sequences indicated that ORF1 encodes a 548-amino-acid protein with a putative membrane-spanning domain and no significant homology to any known protein, while ORF2 and ORF3 show strong homology with the OmpR-EnvZ family of two-component regulatory systems.
Construction and evaluation of a delta cya delta crp Salmonella typhimurium strain expressing avian pathogenic Escherichia coli O78 LPS as a vaccine to prevent airsacculitis in chickens.
The construction of a delta cya delta crp derivative of an avian pathogenic S. typhimurium that expresses both the homologous group B determinants (O1,4,5,12 and the heterologous E. coli O78 LPS O antigens was described, and was stable in vitro and in vivo.
Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment
A biological containment system designed to cause programmed bacterial cell lysis with no survivors is devised and constructed, using Salmonella enterica serovar Typhimurium vaccines for antigen delivery after colonization of host lymphoid tissues.
Immunization with Salmonella enterica Serovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge with Streptococcus pneumoniae
It is established that vesicles can be used to mucosally deliver an antigen from a Gram-positive organism and induce a protective immune response.
Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity.
Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection
It is reported that D23580 causes lethal and invasive disease in a murine model of infection following peroral challenge, the first full duration infection study using an ST313 strain following the entire natural course of disease progression.
Effect of Deletion of Genes Involved in Lipopolysaccharide Core and O-Antigen Synthesis on Virulence and Immunogenicity of Salmonella enterica Serovar Typhimurium
- Qingke Kong, Jiseon Yang, Qing Liu, Praveen Alamuri, K. Roland, R. Curtiss
- BiologyInfection and Immunity
- 18 July 2011
The results indicate that nonreversible truncation of the outer core is not a viable option for developing a live oral Salmonella vaccine, while a wzy mutant that retains one O-antigen unit is adequate for stimulating the optimal protective immunity to homologous or heterologous antigens by oral, intranasal, or intraperitoneal routes of administration.
Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA
- Yuhua Li, Shifeng Wang, R. Curtiss
- Biology, MedicineProceedings of the National Academy of Sciences
- 13 January 2009
A new generation of RASV that exhibit regulated delayed attenuation is designed and constructed that results in highly immunogenic antigen delivery vectors for oral vaccination and elicits significantly greater anti-PspA immune responses than other groups.
The Campylobacter jejuni Dps Homologue Is Important for In Vitro Biofilm Formation and Cecal Colonization of Poultry and May Serve as a Protective Antigen for Vaccination
The importance of Dps for biofilm formation and poultry colonization is demonstrated, and the study provides a basis for continued work using the Dps protein as a vaccine antigen when delivered through a Salmonella vaccine vector.