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Homer: a protein that selectively binds metabotropic glutamate receptors
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, thatExpand
Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit
We have characterized the phosphorylation of the glutamate receptor subunit GluR1, using biochemical and electrophysiological techniques. GluR1 is phosphorylated on multiple sites that are allExpand
Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II*
Modulation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) receptors in the brain by protein phosphorylation may play a crucial role in the regulation of synaptic plasticity. PreviousExpand
Molecular determinants of NMDA receptor internalization
Although synaptic AMPA receptors have been shown to rapidly internalize, synaptic NMDA receptors are reported to be static. It is not certain whether NMDA receptor stability at synaptic sites is anExpand
Regulation of NMDA receptors by phosphorylation
N-methyl-D-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic localization and functional regulation of NMDAExpand
mGluR7 Is a Metaplastic Switch Controlling Bidirectional Plasticity of Feedforward Inhibition
Plasticity of feedforward inhibition in the hippocampal mossy fiber (MF) pathway can dramatically influence dentate gyrus-CA3 dialog. Interestingly, MF inputs to CA3 stratum lucidum interneuronsExpand
PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants
The NMDA receptor NR1 subunit has four splice variants that differ in their C-terminal, cytoplasmic domain. We investigated the contribution of the C-terminal cassettes, C0, C1, C2, and C2', toExpand
AP-3: an adaptor-like protein complex with ubiquitous expression.
We have identified two closely related human proteins (sigma3A and sigma3B) that are homologous to the small chains, sigma1 and sigma2, of clathrin-associated adaptor complexes. Northern and WesternExpand
Subunit-Specific Regulation of NMDA Receptor Endocytosis
At excitatory synapses, both NMDA and AMPA receptors are localized to the postsynaptic density (PSD). However, unlike AMPA receptors, synaptic NMDA receptors are stable components of the PSD. EvenExpand
An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity
PICK1 is a calcium-sensing, PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor (AMPAR) subunits and regulates their trafficking. Although PICK1 has been principallyExpand