• Publications
  • Influence
Nicotine Regulates Multiple Synaptic Proteins by Inhibiting Proteasomal Activity
TLDR
It is found that nicotine, at concentrations achieved by smokers, reduced proteasomal activity, produced accumulation of ubiquitinated synaptic proteins, and increased total protein levels, suggesting that the UPS might participate in nicotine-dependent synaptic plasticity. Expand
Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease
TLDR
Data indicate that sulforaphane activates protein degradation machineries in both the brain and peripheral tissues and may be a therapeutic reagent for Huntington's disease and other intractable disorders. Expand
Direct Reprogramming of Huntington’s Disease Patient Fibroblasts into Neuron-Like Cells Leads to Abnormal Neurite Outgrowth, Increased Cell Death, and Aggregate Formation
TLDR
It is demonstrated that HD patient-derived fibroblasts can be directly trans-differentiated into neuron-like cells by knockdown of the expression of a single gene encoding the polypyrimidine-tract-binding protein. Expand
BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade
TLDR
It is reported that BRCA1 promotes cell survival by directly regulating the DNA damage tolerance pathway in response to agents that create cross-links in DNA. Expand
BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress
TLDR
It is demonstrated that BRCA1 downregulates the kinase activity of PLK1 by modulating the dynamic interactions of Aurora A, hBora, andPLK1, and proposed that in response to replication stress and DNA damage, BRC a1 plays a critical role in downregulating the kinases activity of both CDKs and PLK 1. Expand
Ubiquilin-1 Protects Cells from Oxidative Stress and Ischemic Stroke Caused Tissue Injury in Mice
TLDR
The results suggest that Ubqln protects mice from oxidative stress and ischemic stroke-caused neuronal injury through facilitating removal of damaged proteins, and enhanced removal of unwanted proteins is a potential therapeutic strategy for treating stroke-induced neuronal injury. Expand
UBXD4, a UBX-Containing Protein, Regulates the Cell Surface Number and Stability of α3-Containing Nicotinic Acetylcholine Receptors
TLDR
The data suggest that UBXD4 modulates the distribution of α3* nAChRs between specialized intracellular compartments and the plasma membrane by controlling the stability of the α3 subunit and, consequently, the number of receptors at the cell surface. Expand
Essential Roles of E3 Ubiquitin Ligases in p53 Regulation
  • S. Sane, K. Rezvani
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 1 February 2017
TLDR
This review provides a comprehensive understanding of p53 regulation by selective E3 ubiquitin ligases and their potential to be considered as a new class of biomarkers and therapeutic targets in diverse types of cancers. Expand
Proteasomal degradation of the metabotropic glutamate receptor 1α is mediated by Homer‐3 via the proteasomal S8 ATPase
J. Neurochem. (2012) 122, 24–37.
FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1
TLDR
It is found that the localization of FancJ to the mother centrosome is stimulated by a DNA interstrand crosslinker, Mitomycin C (MMC), and a novel function of FANCJ is uncovered, which is established as an integral part of the ICL response. Expand
...
1
2
3
4
...