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Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
Mice carrying mutations in the fatty liver dystrophy (fld) gene have features of human lipodystrophy, a genetically heterogeneous group of disorders characterized by loss of body fat, fatty liver,Expand
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UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
It has been assumed, based largely on morphologic evidence, that human pluripotent stem cells (hPSCs) contain underdeveloped, bioenergetically inactive mitochondria. In contrast, differentiated cellsExpand
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Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis.
  • K. Takeuchi, K. Reue
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 1 June 2009
Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have important roles in metabolic homeostasis. The molecular identification of genes encoding enzymes thatExpand
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  • Open Access
Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns*
We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally expressed at highExpand
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Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics*
Mutations in the nuclear envelope proteins lamins A and C cause a broad variety of human diseases, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeriaExpand
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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms.Expand
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  • Open Access
Lamin B1 is required for mouse development and nuclear integrity.
Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork that lies beneath the inner nuclear membrane. Lamins play a role in nuclear architecture, DNAExpand
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  • Open Access
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a keyExpand
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Alternatively Spliced Lipin Isoforms Exhibit Distinct Expression Pattern, Subcellular Localization, and Role in Adipogenesis*
We recently identified mutations in the Lpin1 (lipin) gene to be responsible for lipodystrophy in the fatty liver dystrophy (fld) mouse strain. Previous studies revealed that lipin plays a criticalExpand
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Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling shifts the balance ofExpand
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