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Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications
TLDR
Recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell “niches” is highlighted.
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Polyelectrolyte Multilayer Films of Controlled Stiffness Modulate Myoblast Cell Differentiation
TLDR
It is demonstrated that film stiffness strongly modulates adhesion, proliferation and differentiation, each of these processes having its own stiffness requirement.
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Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts.
TLDR
It is shown that crosslinked poly(L-lysine)/hyaluronan (HA) layer-by-layer films can serve as a reservoir for rhBMP-2 delivery to myoblasts and induce their differentiation into osteoblasts in a dose-dependent manner and could find applications in the local delivery of immobilized growth factors for tissue-engineered constructs and for metallic biomaterial surfaces.
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Fast and long-acting antibacterial properties of chitosan-Ag/polyvinylpyrrolidone nanocomposite films.
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Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm.
TLDR
Simultaneous AuNP aggregation within the MRSA biofilm enhanced the photothermal ablation of methicillin-resistant Staphylococcus aureus biofilm under near-infrared (NIR) light irradiation, and the surrounding healthy tissues showed no damage.
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Construction of degradable multilayer films for enhanced antibacterial properties.
TLDR
A system combining the adhesion resistance and the contact killing properties shows an enhanced antibacterial capability through targeting the "decisive period" of implantation, which may have great potential for applications in medical implants, tissue engineering, etc.
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Surface engineering of cardiovascular stent with endothelial cell selectivity for in vivo re-endothelialisation.
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β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner
Matrix-bound BMP-2 is sufficient to induce β3 integrin–dependent, Cdc42/Src/FAK/ILK-mediated cell spreading by overriding the stiffness response through actin and adhesion site dynamics, showing BMP…
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Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo.
TLDR
Direct evidence is provided to support that the PDA surface modification can serve as an effective strategy to form ultrastable coatings on NPs in vivo, which can improve the intracellular delivery capacity and biocompatibility of NPs for biomedical application.
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Enhanced retention and cellular uptake of nanoparticles in tumors by controlling their aggregation behavior.
TLDR
The results suggest that controlled aggregation of NPs sensitive to tumor microenvironment can serve as a universal strategy to enhance the retention and cellular uptake of inorganic NPs in tumors, and modifying NPs with a mixed-charge zwitterionic surface can provide an easy way to obtain stealth properties and pH-sensitivity at the same time.
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