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Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
TLDR
CYP4A1, despite its low expression in extrahepatic tissues, may constitute the major source of 20-HETE synthesis and the ability of CYP4A2 and -4A3 to catalyze the formation of two opposing biologically active metabolites, 20- HETE and 11, 12-epoxyeicosatrienoic acid, may be of great significance to the regulation of vascular tone. Expand
Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells*
TLDR
The data indicate that EETs are potent mitogens for renal epithelial cells, and the mitogenic effects of the E ETs are mediated, at least in part, by the activation of Src kinase and initiation of a tyrosine kinase phosphorylation cascade. Expand
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
TLDR
It is demonstrated that 5-PPInsP5 is the predominant PPIns P5 isomer in Dictyostelium and that 10-25% of the DictYostelia PPInsP 5 pool is comprised of 5- PPInsF5, indicating the cellular spectrum of diphosphoinositol polyphosphates varies across phylogenetic boundaries. Expand
20-HETE agonists and antagonists in the renal circulation.
TLDR
Findings suggest that 20-HETE agonists and antagonists require a carboxyl or an ionizable group on carbon 1 and a double bond near the 14 or 15 carbon, whereas antagonists lack this reactive group. Expand
Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation.
TLDR
The studies indicate that the structural features of 14,15-EET required for relaxation of the bovine coronary artery include a carbon-1 acidic group, a Delta8 double bond, and a 14(S),15(R)-(cis)-epoxy group. Expand
Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses.
TLDR
It is demonstrated that CYP450 hydroxylase and COX arachidonic acid metabolites contribute importantly to the afferent arteriolar diameter and renal microvascular smooth muscle cell calcium responses elicited by ET-1. Expand
Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo.
TLDR
The results suggest that CYP-450-derived HETEs may be important mediators in angiotensin II-induced vasoconstriction, and the development of more sensitive assays for the detection in vivo of 20-HETE in mesenteric vessels would be required to confirm these findings. Expand
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator.
TLDR
The data suggest that 20-HETE is an endogenous product of rabbit airway tissue and may modulate airway resistance in a cyclooxygenase-dependent manner. Expand
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney
TLDR
It is concluded that AII has dual effects on the activity of the apical 70 pS K+ channel: the inhibitory effect is mediated by P450-dependent metabolites whereas the stimulatory effect may be mediated via NO. Expand
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
TLDR
It is suggested that CYP4A1, despite its low expression in extrahepatic tissues, may constitute the major source of 20-HETE synthesis and may be of great significance to the regulation of vascular tone. Expand
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