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Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment
TLDR
It is proposed that selective targeting of proteasome activity with a standardized dose of omega-3-acid ethyl esters, administered to cancer patients diagnosed with early stage CC, in addition to a standard intervention with nutritionally adequate diet and appetite stimulants, will alter metabolic abnormalities by downregulating NFkB, preventing the breakdown of myofibrillar proteins and resulting in increasing serum protein markers, lean body mass, and functional status.
Dexmedetomidine Use in the Setting of Cocaine-Induced Hypertensive Emergency and Aortic Dissection: A Novel Indication
TLDR
The practical beneficial role of Dexmedetomidine in controling blood pressure in the settings of cocaine-induced sympathetic surge when other treatment modalities fail is illustrated.
Neuroactive steroids for the treatment of status epilepticus
TLDR
It is demonstrated that allopregnanolone inhibits ongoing behavioral and electrographic seizures in a model of status epilepticus, even when there is benzodiazepine resistance.
First‐in‐man allopregnanolone use in super‐refractory status epilepticus
TLDR
The first two patients with SRSE who were each successfully treated with a 120‐h continuous infusion of allopregnanolone are described, and both patients recovered from prolonged SRSE with good cognitive outcomes.
SGE‐102: A novel therapy for refractory status epilepticus
TLDR
A randomized double‐blind placebo‐controlled adjunctive trial of SGE will include subjects randomized at the time that initial treatment with anesthesia is initiated, with a 90% chance of detecting a clinically meaningful reduction in seizure recurrence at 120 h.
First-inman allopregnanolone use in super-refractory status epilepticus
TLDR
First-in-man allopregnanolone use in super-refractory status epilepticus Henrikas Vaitkevicius, Aatif M. Husain, Eric S. Rosenthal, Wendell Bobb, Kiran Reddy, Michael A. Rogawski and Andrew J.Rogawski are presented.
Hypertensive Emergencies and Urgencies: A Clinical Guide
TLDR
Critical care physicians should be familiar with all pharmacological and clinical actions of the medications avai lable in treating these hypertensive emergencies, along with the appropriateness of the choice of medication in any given situation.