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Enteric glia mediate neuronal outgrowth through release of neurotrophic factors
Previous studies have shown that transplanted enteric glia enhance axonal regeneration, reduce tissue damage, and promote functional recovery following spinal cord injury. However, the mechanisms byExpand
Neuroactive steroids for the treatment of status epilepticus
Benzodiazepines are the current first‐line standard‐of‐care treatment for status epilepticus but fail to terminate seizures in about one third of cases. Synaptic GABAA receptors, which mediate phasicExpand
First‐in‐man allopregnanolone use in super‐refractory status epilepticus
Super‐refractory status epilepticus (SRSE) is associated with high morbidity and mortality. Treatment of SRSE is complicated by progressive cortical hyperexcitability believed to result in part fromExpand
SGE‐102: A novel therapy for refractory status epilepticus
Refractory status epilepticus (SE) has a mortality rate of up to 35%. Current treatment protocols for the treatment of SE begin with benzodiazepines and then proceed to conventional anticonvulsants.Expand
Young blood rejuvenates old brains
Age-related cognitive decline occurs in many mammals, including humans, resulting from a decline in hippocampal function, and it is associated with reduced synaptic plasticity in hippocampalExpand
First-inman allopregnanolone use in super-refractory status epilepticus
First-in-man allopregnanolone use in super-refractory status epilepticus Henrikas Vaitkevicius , Aatif M. Husain, Eric S. Rosenthal , Jonathan Rosand, Wendell Bobb, Kiran Reddy, Michael A. Rogawski &Expand
Background: Fluoroquinolones are a popular class of antibiotics used in variety of infections. However, toxicities are associated with these agents of which seizure provoking action ofExpand
Formulation de stéroïde neuroactif et procédés de traitement des troubles de snc
La presente invention concerne des formulations comprenant un steroide neuroactif, par ex., l'allopregnanolone ; et facultativement une cyclodextrine, par ex. une β-cyclodextrine, par ex., uneExpand
Human Enteric Glial Cells Alleviate Damaged Adult Sensory Neurons in Rats
Spinal cord injury affects millions across the globe. Little is known regarding the cellular mechanism of injury and, unfortunately, there are few viable treatment options. One potential option isExpand