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The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.
First identified as a neutrophil granule component, neutrophil gelatinase-associated lipocalin (NGAL; also called human neutrophil lipocalin, 24p3, uterocalin, or neu-related lipocalin) is a memberExpand
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Enterobactin: An archetype for microbial iron transport
Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is aExpand
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Effect of hydroxamate siderophores on Fe release and Pb(II) adsorption by goethite
Abstract Hydroxamate siderophores are biologically-synthesized, Fe(III)-specific ligands which are common in soil environments. In this paper, we report an investigation of their adsorption by theExpand
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The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Numerous bacteria cope with the scarcity of iron in their microenvironment by synthesizing small iron-scavenging molecules known as siderophores. Mammals have evolved countermeasures to blockExpand
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Microbial iron transport via a siderophore shuttle: a membrane ion transport paradigm.
A mechanism of ion transport across membranes is reported. Microbial transport of Fe(3+) generally delivers iron, a growth-limiting nutrient, to cells via highly specific siderophore-mediatedExpand
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Anthrax pathogen evades the mammalian immune system through stealth siderophore production
Systemic anthrax, caused by inhalation or ingestion of Bacillus anthracis spores, is characterized by rapid microbial growth stages that require iron. Tightly bound and highly regulated in aExpand
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Petrobactin-mediated iron transport in pathogenic bacteria: coordination chemistry of an unusual 3,4-catecholate/citrate siderophore.
The hexadentate 3,4-catecholate/citrate siderophore petrobactin is produced by the mammalian pathogens Bacillus anthracis and Bacillus cereus apparently to evade the immune protein siderocalin andExpand
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Solution equilibria of enterobactin and metal-enterobactin complexes
The solution thermodynamics of the siderophore enterobactin, a powerful iron chelator, and of the synthetic analogue MECAM (N,N',N″-tris(2,3-dihydroxybenzoyl)-1,3,5-tris(aminomethyl)benzene) haveExpand
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