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Modeling of presymptomatic and symptomatic stages of parkinsonism in mice
TLDR
The models of the early and advanced presymptomaic stages and of theEarly symptomatic stage of parkinsonism were developed in mice with MPTP and might be exploited for an examination of pathogenetic mechanisms not only in the nigrostriatal system but also in other brain regions and in the periphery. Expand
Chronic neonatal N-methyl-d-aspartate receptor blockade induces learning deficits and transient hypoactivity in young rats
TLDR
Even mild chronic neonatal blockade of NMDA receptors may lead to a specific pattern of cognitive abnormalities presumably resulting from impairments of sensory information processing at the cortical-basal ganglia level. Expand
Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake.
TLDR
It is indicated that in rat striatum, a tolcapone-induced increase in extracellular dopamine is not observed because of the presence of uptake, and this results support the hypothesis that under normal conditions, uptake, rather than metabolism, controlextracellular levels of dopamine. Expand
Effects of a psychostimulant drug sydnocarb on rat brain dopaminergic transmission in vivo.
TLDR
Data suggest that the stimulant action of sydnocarb is accompanied by a facilitation of central dopaminergic transmission involving an increase in Ca2+-dependent vesicular dopamine efflux. Expand
In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis.
TLDR
The present results give further support to the hypothesis that the dopamine D3 autoreceptor is preferentially involved in the presynaptic regulation of dopamine release, while the D2 autore receptor controls dopamine synthesis. Expand
Regulation of dopamine release and metabolism in rat striatum in vivo: Effects of dopamine receptor antagonists
TLDR
It is concluded that typical and atypical antipsychotic drugs might be clearly distinguished on the basis of their ability to affect preferentially DA synthesis/metabolism or release in rat dorsal striatum in vivo. Expand
Dopamine turnover in the mediobasal hypothalamus in rat fetuses
TLDR
Dopamine is synthesized and released in response to a membrane depolarization in the mediobasal hypothalamus of rats as early as the end of intrauterine development, suggesting its contribution to the inhibitory control of pituitary prolactin secretion. Expand
Dopamine synthesis by non-dopaminergic neurons expressing individual complementary enzymes of the dopamine synthetic pathway in the arcuate nucleus of fetal rats
TLDR
This study provides convincing evidence of cooperative DA synthesis by non-DAergic neurons expressing TH or AADC in fetal rats at the end of the intrauterine development. Expand
Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures
TLDR
The administration of N-nitro-l-arginine (L-NNA), a competitive inhibitor of NO-synthase, at the dose of 250 mg/kg, completely prevented the NO increase induced by PTZ, although clonic convulsions in the animals have been observed. Expand
Effects of amphetamine and sydnocarb on dopamine release and free radical generation in rat striatum
TLDR
It is concluded that the psychostimulant action of sydnocarb is accompanied by facilitation of the central dopaminergic transmission in rat neostriatum and followed by less pronounced neurotoxic effect than that of D-amphetamine. Expand
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