• Publications
  • Influence
Life on the inside: the intracellular lifestyle of cytosolic bacteria
TLDR
The mechanisms by which cytosolic pathogens escape into the cytosol, obtain nutrients to replicate and subvert host immune responses are discussed.
NAFLD—the next global epidemic
  • K. Ray
  • Biology
    Nature Reviews Gastroenterology &Hepatology
  • 1 November 2013
TLDR
A special focus issue on NAFLD is commissioned to provide a comprehensive overview that covers the breadth of basic, translational and clinical research on this complex condition and explores the latest evidence from clinical trials on the pharmacological agents currently available to treat NASH and the new therapies that are emerging.
Tracking the dynamic interplay between bacterial and host factors during pathogen‐induced vacuole rupture in real time
TLDR
A novel, robust and sensitive fluorescence microscopy method is established that tracks the precise time point of vacuole rupture upon uptake of Gram‐negative bacteria and shows that the enteroinvasive pathogen Shigella flexneri escapes rapidly, in less than 10 min, from the vacuoles.
Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production
TLDR
Synthetic small interfering RNA sequences targeting the human Notch ligands Delta1, Jagged1 and Jagged2 are described, showing for the first time that the Notch pathway can be targeted by siRNA, and that its antagonism may be a unique therapeutic opportunity for immune enhancement.
Liver: Hepatic stellate cells hold the key to liver fibrosis
  • K. Ray
  • Medicine, Biology
    Nature Reviews Gastroenterology &Hepatology
  • 1 February 2014
TLDR
It is determined that HSCs do not function as epithelial progenitors and have no role in the generation of new hepatocytes in the context of liver injury, a matter of much controversy previously.
Colorectal cancer: Fusobacterium nucleatum found in colon cancer tissue—could an infection cause colorectal cancer?
  • K. Ray
  • Biology, Medicine
    Nature Reviews Gastroenterology &Hepatology
  • 15 November 2011
Colorectal cancer: Fusobacterium nucleatum found in colon cancer tissue—could an infection cause colorectal cancer?
Rheumatoid arthritis: Clue to role of cannabinoid receptors in RA
  • K. Ray
  • Medicine
    Nature Reviews Rheumatology
  • 4 February 2014
Gut microbiota: Colorectal cancer—driven by inflammation and gut bacteria?
  • K. Ray
  • Biology, Medicine
    Nature Reviews Gastroenterology &Hepatology
  • 4 September 2012
TLDR
Findings point to a novel mechanism by which intestinal inflammation promotes the development of colitis-associated CRC, by modulating the genotoxic capacity of the microbiota, according to team leader Christian Jobin.
Hepatitis: NPC1L1 identified as a novel HCV entry factor
  • K. Ray
  • Medicine
    Nature Reviews Gastroenterology &Hepatology
  • 14 February 2012
Gut microbiota: Married to our gut microbiota
  • K. Ray
  • Medicine, Biology
    Nature Reviews Gastroenterology &Hepatology
  • 1 October 2012
TLDR
This special Focus issue on the gut microbiota is commissioned to highlight the latest research, translate these findings into clinical practice and set the stage for future developments.
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