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PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule.
- B. L. Nanda, A. Nataraju, R. Rajesh, K. Rangappa, M. Shekar, B. Vishwanath
- Chemistry, BiologyCurrent topics in medicinal chemistry
- 31 March 2007
In this line, molecules having both anti-oxidant and PLA2 inhibitions are reviewed and a single molecule with dual activities may prove to be a powerful anti-inflammatory drug.
Extractive spectrophotometric methods for the assay of sildenafil citrate (Viagra) in pure form and in pharmaceutical formulations.
Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy.
- K. Mantelingu, A. H. Kishore, T. Kundu
- Chemistry, BiologyThe journal of physical chemistry. B
- 7 April 2007
The synthesis of trifluoromethyl phenyl benzamides and their effect on histone acetyltransferase (HAT) activity of p300 is reported and Raman spectroscopic analysis of the complexes of histone-modifying enzymes and their modulators are described, for the first time, which may be highly useful for therapeutic applications.
A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status.
Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress
Overall, TSE was observed as a potent agent abrogating arthritis-mediated cartilage/bone degradation, inflammation and associated stress in vivo demanding further attention.
Simple and an efficient method for the synthesis of 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol hydrochloride: (+/-) venlafaxine racemic mixtures.
Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials.
Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells.