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PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule.
TLDR
In this line, molecules having both anti-oxidant and PLA2 inhibitions are reviewed and a single molecule with dual activities may prove to be a powerful anti-inflammatory drug.
Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy.
TLDR
The synthesis of trifluoromethyl phenyl benzamides and their effect on histone acetyltransferase (HAT) activity of p300 is reported and Raman spectroscopic analysis of the complexes of histone-modifying enzymes and their modulators are described, for the first time, which may be highly useful for therapeutic applications.
Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress
TLDR
Overall, TSE was observed as a potent agent abrogating arthritis-mediated cartilage/bone degradation, inflammation and associated stress in vivo demanding further attention.
Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinoma.
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