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GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.
With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasiveExpand
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Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters.
Escherichia coli was grown in hyperosmotic media containing both glycine betaine and one other betaine. E. coli K-12 derivative WG439 (putP- proP- proU-) did not accumulate any of 15 betaines.Expand
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Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis
1 Criteria for distinguishing dopamine autoreceptor agonism from other mechanisms of inhibiting locomotion were examined, together with the relationship between inhibition of locomotion and dopamineExpand
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The cortical neuritic pathology of Huntington's disease
We have studied the brains of 10 patients with clinically and pathologically defined Huntington's disease and graded the degree of striatal pathology according to the Vonsattel grading system.Expand
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Osmoprotective properties and accumulation of betaine analogues by Staphylococcus aureus.
Betaines were evaluated as potential antistaphylococcal agents for urinary tract infections. Staphylococcus aureus accumulated all tested betaines except trigonelline. S. aureus transport systemsExpand
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Natural and synthetic betaines counter the effects of high NaCl and urea concentrations.
Escherichia coli was used as a model system to evaluate a range of betaines for their ability to protect against salt and urea stresses. Betaine structure determined the salt and urea protectiveExpand
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Osmoprotective activity, urea protection, and accumulation of hydrophilic betaines in Escherichia coli and Staphylococcus aureus
The hydrophilic betaines, deanol betaine, triethanol betaine, diethanolthetin and methylethanolthetin, and also thioxanium betaine and citrulline betaine, were accumulated by Escherichia coli. AllExpand
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Inhibitors of bacterial growth in urine: what is the role of betaines?
It has long been recognised that some individuals produce urine that is inhibitory to uropathogens. This may be partly explained by inhibitors. Several inhibitors have been identified in urineExpand
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Relationship between osmoprotection and the structure and intracellular accumulation of betaines by Escherichia coli.
Naturally occurring betaines, especially glycine betaine and proline betaine, were accumulated by Escherichia coli from urine. In synthetic hyperosmotic medium, with an homologous series of addedExpand
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Accumulation of natural and synthetic betaines by a mammalian renal cell line.
Intracellular accumulation of different betaines was compared in osmotically stressed Madin Darby canine kidney (MDCK) cells to model the betaine accumulation specificity of the mammalian innerExpand
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