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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease.
Clustering of 770,000 genomes reveals post-colonial population structure of North America
This work identifies very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin.
Patterns of second primary malignancy risk in multiple myeloma patients before and after the introduction of novel therapeutics
- P. Razavi, K. Rand, W. Cozen, A. Chanan-Khan, S. Usmani, S. Ailawadhi
- Medicine, BiologyBlood cancer journal
- 1 June 2013
On the basis of observed trends for overall SPM as well as AML, no association between the introduction of novel therapies and SPM following MM has emerged in this large population-based study.
The contribution of rare variation to prostate cancer heritability
We report targeted sequencing of 63 known prostate cancer risk regions in a multi-ancestry study of 9,237 men and use the data to explore the contribution of low-frequency variation to disease risk.…
Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating
It is concluded that the true heritability of human longevity for birth cohorts across the 1800s and early 1900s was well below 10%, and that it has been generally overestimated due to the effect of assortative mating.
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.
This study conducted fine mapping of the 8q24 risk region in search of novel associations with common and rare variation in men of African ancestry and identified three independent associations at P values of less than 5.00×10(-8).
AncestryDNA COVID-19 Host Genetic Study Identifies Three Novel Loci
New evidence is presented that host genetic variation likely contributes to COVID-19 outcomes and the value of large-scale, self-reported data as a mechanism to rapidly address a health crisis is demonstrated.
A Prospective Analysis of Genetic Variants Associated with Human Lifespan
A genome-wide association study using a de-identified snapshot of the unique AncestryDNA database and a meta-analysis of more than 650,000 individuals identified fifteen parental lifespan-associated loci that represent a large fraction of the heritability estimated from phenotypic correlations between relatives.
A genome-wide association study of prostate cancer in West African men
- M. Cook, Zhaoming Wang, African Ancestry Prostate Cancer Gwas Consortium
- Biology, MedicineHuman Genetics
- 1 May 2014
A genome-wide association study of prostate cancer in West African men in the Ghana Prostate Study found the most promising association was at 10p14 within an intron of a long non-coding RNA (lncRNA RP11-543F8) of GATA3, and sought to validate the findings in silico in the African Ancestry Prostate Cancer GWAS Consortium.