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Naloxone-precipitated abstinence in mice, rats and gerbils acutely dependent on morphine.

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Omeprazole Disposition in Children following Single‐Dose Administration

In children ages 2 to 16 years receiving 10 or 20 mg of omeprazole as a single oral dose, the PK are quite comparable to values reported for adults, and in pediatric patients who are CYP2C19 extensive metabolizers, there was no association between genotype and the pharmacokinetics of omEPrazole.
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Tail immersion test for the evaluation of a nociceptive reaction in mice. Methodological considerations.

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Opioid antagonists, endogenous ligands and nociception.

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Stereospecific effects of opiate antagonists on superficial and deep nociception and on motor activity suggest involvement of endorphins on different opioid receptors.

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Endogenous opioid peptides and epilepsy.

The aim of this review is to summarize some of the recent findings on the link between the endogenous opioid peptides and epilepsy.
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Neuromuscular effects of some opioid agonists and antagonists.

The effects of morphine, pethidine, (-) naloxone, N-methylnaloxone, naltrexone and levallorphan on acetylcholine-induced contraction of the toad rectus were studied. The drugs were shown to inhibit…
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Effects of the benzomorphan kappa-opiate, MR 2266 and its (+) enantiomer MR 2267, on thermonociceptive reactions in different strains of mice.

The results indicate the presence of tonic kappa-receptor-mediated regulation of the spinal and supra-spinal thermonociceptive reactions which is stereospecific and strain dependent.
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ENHANCEMENT OF A NOCICEPTIVE REACTION BY OPIOID ANTAGONISTS IN MICE

The enhancing effect of naloxone may be due to an antagonism of endogenous ligands for the opiate receptor and these ligands would be involved in reaction to but not in perception of nociceptive stimuli which need not be harmful ones.
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Role of opiate receptors and endogenous ligands in nociception.

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