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Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
TLDR
Combining the mutant p53-inactivating agent APR-246 (PRIMA-1MET) with the proteasome inhibitor carfilzomib is effective in overcoming chemoresistance in triple-negative breast cancer cells, creating a therapeutic opportunity for treatment of solid tumours and metastasis with mutant p53.
Probiotic properties of yeasts isolated from chicken feces and kefirs.
TLDR
All the tested strains survived in sufficient number to create the possibility of proper action in the human body, although fecal, probiotic and collection strains tolerated the conditions of the human gastrointestinal tract better than food-borne yeasts.
Selected Essential Oils as Antifungal Agents Against Antibiotic-Resistant Candida spp.: In Vitro Study on Clinical and Food-Borne Isolates.
TLDR
High antifungal activity of examined EOs against Candida clinical and food-borne strains, including antibiotic-resistant isolates, indicates their usefulness as agents preventing the development of Candida strains of different origin.
Antibiotics sensitivity of Candida clinical and food-borne isolates.
TLDR
The sensitivity of four antibiotics belonging to three different groups of antifungal agents against clinical and food-borne Candida strains was determined to show that of all tested strains, 7% was resistant to nystatin, 32% to fluconazole, 23% to voriconazoles, and no strains grew in the presence of caspofungin.
Quaternary ammonium biocides as antimicrobial agents protecting historical wood and brick.
TLDR
Staphylococcus equorum, Bacillus cereus, Sporosarcina aquimarina and Rhodococcus fascians bacteria, and Cladosporium cladosporioides I and Acremonium strictum moulds showed high sensitivity to quaternary ammonium biocides.
Abiotic Determinants of the Historical Buildings Biodeterioration in the Former Auschwitz II – Birkenau Concentration and Extermination Camp
TLDR
Inside the buildings, molds and bacteria were not found to develop actively, while algae and wood-decaying fungi occurred locally, and the factors conducive to biological corrosion in the studied buildings were excessive dampness of structural partitions close to the ground and a relative air humidity of above 70%, which was connected to ineffective moisture insulation.
Probiotic Activity of Saccharomyces cerevisiae var. boulardii Against Human Pathogens
TLDR
The probiotic activity of S. boulardii against human pathogens is related to a decrease in the number of viable and active cells of bacteria and the binding capacity of yeasts, which may limit bacterial invasiveness and prevent bacterial adherence and translocation in the human intestines.
Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model
TLDR
This splice-switching class of molecules is the first to specifically correct the ELP1 exon 20 splicing defect, providing proof of principle of ExSpeU1s-adeno-associated virus particles as a novel therapeutic strategy for FD.
Protection of Historical Wood against Microbial Degradation—Selection and Application of Microbiocides
TLDR
Results from this study were used to develop a procedure for the protection of wood in historical buildings against biodeterioration.
Phenotypic and genotypic diversity of wine yeasts used for acidic musts
TLDR
Changes in karyotypes and mtDNA profiles prove that fermentative stress is the main driving force of the adaptive evolution of the yeasts, and karyotyping even though it does not seem to be a good discriminative tool, can be useful in determining the stability of wine yeasts.
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