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Risk assessment in neonatal early onset sepsis.
TLDR
The development of multivariate predictive models may provide more accurate methods of identifying newborns at highest risk and allow for more limited newborn antibiotic exposures.
A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis
TLDR
Clinical care algorithms based on individual infant estimates of EOS risk derived from a multivariable risk prediction model reduced the proportion of newborns undergoing laboratory testing and receiving empirical antibiotic treatment without apparent adverse effects.
Interpreting Complete Blood Counts Soon After Birth in Newborns at Risk for Sepsis
TLDR
Optimal interpretation of the CBC requires using interval likelihood ratios for the newborn's age in hours, especially for WBC counts and ANCs, which improved with age in the first few hours.
Estimating the Probability of Neonatal Early-Onset Infection on the Basis of Maternal Risk Factors
TLDR
A quantitative model is developed that establishes a prior probability for newborn sepsis, which could be combined with neonatal physical examination and laboratory values to establish a posterior probability to guide treatment decisions.
Stratification of Risk of Early-Onset Sepsis in Newborns ≥34 Weeks’ Gestation
TLDR
It is possible to combine objective maternal data with evolving objective neonatal clinical findings to define more efficient strategies for the evaluation and treatment of EOS in term and late preterm infants.
SARS-CoV-2 seroprevalence among parturient women in Philadelphia
TLDR
Serological tests among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community and race/ethnicity differences in seroprevalence rates.
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios.
TLDR
The findings demonstrate the potential for maternally derived SARS-CoV-2 specific antibodies to provide neonatal protection from coronavirus disease 2019, as transferred across the placenta after asymptomatic as well as symptomatic infection during pregnancy.
Management of Neonates Born at ≥35 0/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis
TLDR
The purpose in this clinical report is to provide a summary of the current epidemiology of neonatal sepsis among infants born at ≥35 0/7 weeks’ gestation and a framework for the development of evidence-based approaches to sepsi risk assessment among these infants.
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