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Apoptosis in human acute myocardial infarction.
TLDR
This study provides evidence that in addition to overt necrosis, a subset of myocytes undergo apoptosis during ischemia-reperfusion injury and may provide a new target for cardioprotection during evolving AMI in humans.
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis.
TLDR
Doxorubicin-induced cardiotoxicity involves cardiomyocyte apoptosis, a potentially preventable form of myocardial tissue loss, and alterations in the cytoskeletal apparatus with focal loss of contractile elements were seen after a single injection.
Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats.
TLDR
The increase in diastolic diameter 1-4 wk after infarction correlated with cardiomyocyte apoptosis in the noninfarcted myocardium, which quantitatively contributed most (>50%) to the apoptotic cell loss by 4 wk.
Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial.
TLDR
Compared with SFA intake, n-6 PUFAs reduce liver fat and modestly improve metabolic status, without weight loss.
Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency
TLDR
Analysis of the prevalence of the various mutations among DPD patients has shown that the G→A point mutation in the invariant splice donor site is by far the most common (52%), whereas the other six mutations are less frequently observed.
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from
TLDR
Non-fasting blood samples should be routinely used for the assessment of plasma lipid profiles and laboratory reports should flag abnormal values on the basis of desirable concentration cut-points to improve patient compliance with lipid testing.
Circulating Pregnancy-Associated Plasma Protein A Predicts Outcome in Patients With Acute Coronary Syndrome but No Troponin I Elevation
TLDR
Measurement of plasma PAPP-A, a zinc-binding matrix metalloproteinase, is a strong independent predictor of ischemic cardiac events and need of revascularization in patients who present with suspected myocardial infarction but remain troponin negative.
Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex.
TLDR
It is demonstrated that the main part of cTnI in serum collected from acute myocardial infarction patients is presented in the complex from CTnC, which results in a significant decrease of the interaction of mAbs with TnI.
Markers of renal function and acute kidney injury in acute heart failure: definitions and impact on outcomes of the cardiorenal syndrome.
TLDR
Cystatin C appears to be a useful marker of early AKI in patients hospitalized for AHF, and a decline in renal function detected by cyStatin C during the first 48 h after hospitalization occurs frequently in AHF and has a detrimental impact on prognosis.
Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
TLDR
PCT concentrations were higher in more severe forms of severe sepsis, but a substantial concentration decrease was more important for survival than absolute values.
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