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Osteoarthritis cartilage histopathology: grading and staging.
OBJECTIVE Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was toExpand
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Histological Assessment of Cartilage Repair: A Report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS)
Physical injury frequently causes tissue damage, including laceration. Repair of the damage usually results in the formation of a scar; complete anatomic healing and true regeneration are rare. Expand
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Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa.
Two transglutaminases (TGases), Factor XIIIa and tissue TGase (tTGase), are expressed in temporal-spatial association with matrix calcification in growth plates. Meniscal and articular cartilageExpand
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TLR2 Signaling in Chondrocytes Drives Calcium Pyrophosphate Dihydrate and Monosodium Urate Crystal-Induced Nitric Oxide Generation1
Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU) deposited in synovium and articular cartilage initiate joint inflammation and cartilage degradation in large part byExpand
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Subchondral bone in osteoarthritis
SummaryTo determine whether subchondral bone in osteoarthritis differs from that seen in normal human aging, osteoarthritic femoral heads removed for total hip arthroplasty were compared with normalExpand
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Matrix Vesicle Plasma Cell Membrane Glycoprotein‐1 Regulates Mineralization by Murine Osteoblastic MC3T3 Cells
A naturally occurring nonsense truncation mutation of the inorganic pyrophosphate (PPi)‐generating nucleoside triphosphate pyrophosphohydrolase (NTPPPH) PC‐1 is associated with spinal andExpand
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Fresh small-fragment osteochondral allografts. Long-term follow-up study on first 100 cases.
Of 100 patients receiving fresh osteochondral fragment allografts, 95 had replacement of the weight-bearing portion of the knee. The allografts excised under sterile conditions were stored inExpand
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Effects of the Steroidal Aromatase Inhibitor Exemestane and the Nonsteroidal Aromatase Inhibitor Letrozole on Bone and Lipid Metabolism in Ovariectomized Rats
Purpose: Exemestane (EXE) and letrozole (LET) are third-generation aromatase inhibitors currently prescribed for postmenopausal hormone-dependent breast cancer. The impact on end organs of estrogenExpand
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High Frequency Acoustic Parameters of Human and Bovine Articular Cartilage following Experimentally-Induced Matrix Degradation
Matrix degradation and proteoglycan loss in articular cartilag eare features of early osteoarthritis. To determine the effect of matrix degradation and proteoglycan loss on ultrasound propagation inExpand
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Natural history of spontaneous osteonecrosis of the knee (SONK): a review.
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