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GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
Golgi-localized, gamma ear-containing, ADP ribosylation factor-binding (GGA) proteins have been shown to be implicated in the sorting of cargo proteins from the trans-Golgi network (TGN) to endosomalExpand
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Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis
Presenilins (PSs) are components of the γ-secretase complex that mediates intramembranous cleavage of type I membrane proteins. We show that γ-secretase is involved in the regulation of cellularExpand
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Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
Alzheimer disease is associated with extracellular deposits of amyloid beta-peptides in the brain. Amyloid beta-peptides are generated by proteolytic processing of the beta-amyloid precursor proteinExpand
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Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.
Matriptase-2 is a member of the TTSPs (type II transmembrane serine proteases), an emerging class of cell surface proteases involved in tissue homoeostasis and several human disorders. Matriptase-2Expand
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Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11
Here, we report the development and further characterisation of a novel PrP-specific monoclonal antibody: 2A11. By Western blot analysis, 2A11 reacts with PrPC from a variety of species includingExpand
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A Structural Switch of Presenilin 1 by Glycogen Synthase Kinase 3β-mediated Phosphorylation Regulates the Interaction with β-Catenin and Its Nuclear Signaling*
Presenilins (PS) are critical components of the γ-secretase complex that mediates cleavage of type I membrane proteins including the β-amyloid precursor protein to generate the amyloid β-peptide. InExpand
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Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]
Alzheimer disease is associated with extracellular deposits of amyloid β-peptides in the brain. Amyloid β-peptides are generated by proteolytic processing of the β-amyloid precursor protein by β- andExpand
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Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging*
Processing of amyloid precursor protein (APP) is a well acknowledged central pathogenic mechanism in Alzheimer disease. However, influences of age-associated cellular alterations on the biochemistryExpand
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Long term survival in non-encapsulated primary liposarcoma of the mediastinum.
An elderly woman presented with dyspnoea secondary to extensive mediastinal invasion by a primary well differentiated liposarcoma of the mediastinum. Five years after partial resection andExpand
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